Efficacy and Safety Analysis of Botox Application and Iatrogenic Botulism: Panacea or Peril?

Basit Öğe Kaydı
dc.contributor.authorKarcioglu, Ozgur
dc.contributor.authorAkman, Canan
dc.contributor.authorAtnis, Ilknur
dc.date.accessioned2025-01-27T21:03:34Z
dc.date.available2025-01-27T21:03:34Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractClostridium botulinum toxin-A (BoNT-A) creates temporary paralysis in the muscles by acting on the muscle-nerve junction. It is injected into the mimic muscles when a decrease in the movements of the mimic muscles is desired. Despite many favorable applications, the use of BoNT-A is not without drawbacks. Although there is no expected serious side effect on health in BoNT-A treatments, various problems can be encountered in patients treated for aesthetic purposes. Botulism is a rare but potentially life-threatening syndrome, which is caused by the toxin produced by the bacterium Clostridium botulinum, which acts on the nervous system, vegetative forms of C. botulinum can only survive in anaerobic conditions, while spore forms are common in nature and can withstand harsh conditions. Botulism can stem from bacterial spores which release toxin in the body; in the form of enteric botulism, and wound botulism. The cases that develop 'iatrogenic botulism' after such procedures are usually those receiving high-dose toxin for therapeutic purposes. The treatment of botulism mainly consists of anti-toxin therapy and, if necessary, intensive care to prevent organ failures, including respiratory support. This article aims to cover all these issues related to botulism and other adverse outcomes related to BoNT-A injection in light of the most recent literature.
dc.identifier.doi10.2174/0113816128284720240212111926
dc.identifier.endpage588
dc.identifier.issn1381-6128
dc.identifier.issn1873-4286
dc.identifier.issue8
dc.identifier.pmid38409723
dc.identifier.scopus2-s2.0-85187874638
dc.identifier.scopusqualityQ2
dc.identifier.startpage578
dc.identifier.urihttps://doi.org/10.2174/0113816128284720240212111926
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27339
dc.identifier.volume30
dc.identifier.wosWOS:001202973800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Design
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectClostridium botulinum
dc.subjectbotulinum toxin
dc.subjectBotox
dc.subjectbotulism
dc.subjectiatrogenic botulism
dc.subjectparesis
dc.subjectrespiratory paralysis
dc.titleEfficacy and Safety Analysis of Botox Application and Iatrogenic Botulism: Panacea or Peril?
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu