PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY-2: Novel amide/Ntr combinations targeting PC3 cancer cells
dc.authorid | Gungor, Tugba/0000-0001-5261-1856 | |
dc.authorid | Celik, Ayhan/0000-0003-1355-9252 | |
dc.authorid | TASKIN-TOK, Tugba/0000-0002-0064-8400 | |
dc.authorid | Comert Onder, Ferah/0000-0002-4037-1979 | |
dc.authorid | AY, Mehmet/0000-0002-1095-1614 | |
dc.contributor.author | Gungor, Tugba | |
dc.contributor.author | Onder, Ferah Comert | |
dc.contributor.author | Tokay, Esra | |
dc.contributor.author | Gulhan, Unzile Guven | |
dc.contributor.author | Hacioglu, Nelin | |
dc.contributor.author | Tok, Tugba Taskin | |
dc.contributor.author | Celik, Ayhan | |
dc.date.accessioned | 2025-01-27T20:16:40Z | |
dc.date.available | 2025-01-27T20:16:40Z | |
dc.date.issued | 2019 | |
dc.department | Çanakkale Onsekiz Mart Üniversitesi | |
dc.description.abstract | The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration of drugs at cancer cells is remarkable. Discovery of new prodrugiNTR combinations is necessary to be an alternative to known prodrug candidates such as CB1954, SN23862, PR 104A. For this aim, nitro containing aromatic amides (A1-A23)(2) were designed, synthesized, performed in silico ADMET and molecular docking techniques in this study. Prodrug candidates were studied on reduction potentials with Ssap-NtrB by HPLC system. Also, cyototoxic properties and prodrug ability of these amides were investigated using different cancer cell lines such as Hep3B and PC3. As a result of theoretical and biological studies, combinations of A5, A6 and A20 with Ssap-NtrB can be suggested as potential prodrugs/enzyme combinations at NTR based cancer therapy compared with CB1954/NfsB. (C) 2019 Elsevier Masson SAS. All rights reserved. | |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey-TUBITAK [110T754, 113Z706] | |
dc.description.sponsorship | This study was financially supported by a research grant from Scientific and Technological Research Council of Turkey-TUBITAK (Grant No. 110T754 and 113Z706). Sincere thanks to Gizem TATAR for her supports to help computational part of this study. The numerical calculations reported in this abstract were fully performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources). | |
dc.identifier.doi | 10.1016/j.ejmech.2019.03.035 | |
dc.identifier.endpage | 400 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.issn | 1768-3254 | |
dc.identifier.pmid | 30928710 | |
dc.identifier.scopus | 2-s2.0-85063547110 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.startpage | 383 | |
dc.identifier.uri | https://doi.org/10.1016/j.ejmech.2019.03.035 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12428/21340 | |
dc.identifier.volume | 171 | |
dc.identifier.wos | WOS:000466254500026 | |
dc.identifier.wosquality | Q1 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier | |
dc.relation.ispartof | European Journal of Medicinal Chemistry | |
dc.relation.publicationcategory | info:eu-repo/semantics/openAccess | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.snmz | KA_WoS_20250125 | |
dc.subject | Nitro aromatic amides | |
dc.subject | Prodrug | |
dc.subject | Ssap-NtrB | |
dc.subject | Enzymatic activity | |
dc.subject | Cytotoxicity | |
dc.subject | Molecular docking | |
dc.title | PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY-2: Novel amide/Ntr combinations targeting PC3 cancer cells | |
dc.type | Article |