The effects of exhaustive swimming and probiotic administration in trained rats: Oxidative balance of selected organs, colon morphology, and contractility

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dc.authoridYıldız, Mustafa/0000-0003-4128-8947
dc.authoridGules, Ozay/0000-0001-6170-1706
dc.authoridEKREN ASICI, GAMZE SEVRI/0000-0002-9625-7956
dc.authoridBoyacioglu, Murat/0000-0001-6952-8637
dc.authoridEKICI, MEHMET/0000-0002-2163-6214
dc.authoridKOC YILDIRIM, Ece/0000-0002-3208-6772
dc.contributor.authorUnsal, C.
dc.contributor.authorUnsal, H.
dc.contributor.authorEkici, M.
dc.contributor.authorYildirim, E. Koc
dc.contributor.authorUner, A. G.
dc.contributor.authorYildiz, M.
dc.contributor.authorGules, O.
dc.date.accessioned2025-01-27T20:22:29Z
dc.date.available2025-01-27T20:22:29Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe duration and intensity of exercise are significant factors in oxidative, morphological, and functional changes of the gastrointestinal tract. This study aimed to investigate the effects of both exhaustive swimming and probiotic VSL#3 on rats that had been previously trained with moderate swimming. The rats were divided into four groups labeled: control (C), probiotic (P), exercise (E), and probiotic-exercise (PE). Groups P and PE were fed with probiotic mixture VSL#3. Groups E and PE had a 5-week moderate swimming program (1 h/day for 5 days/week), followed by a 1-week exhaustive swimming program (trained like in moderate program but 3 times with 150 min resting sessions, for 5 days/week). At the end of the program, the rats were euthanized. Malondialdehyde, superoxide dismutase, catalase, and reduced glutathione levels were measured in tissue samples from the gastrocnemius muscle, heart, liver, kidney, and colon. In vitro contractile activity and histomorphology of the colon were also determined. Exercise and/or probiotic decreased the oxidative stress and also increased the level of one or more of the antioxidant enzymes in some of the organs. Probiotics had more pronounced effects on colon morphology than exercise but unexpectedly this effect was non-trophic. In the colon, the thickness of the tunica muscularis and the number of goblet cells were not affected; however, probiotic administration decreased the crypt depth and tunica mucosa thickness. Exercise increased the Emax value of acetylcholine (ACh), while decreased its sensitivity. These findings suggest that exhaustive swimming does not cause oxidative stress and that probiotic consumption improves oxidative balance in trained rats. The probiotic intake does not alter the effect of exercise on the contractile activity of the colon. Colon mucosal changes induced by probiotics are independent of exercise.
dc.description.sponsorshipAdnan Menderes University Research Fund [VTF14017]
dc.description.sponsorshipThis study was funded by the Adnan Menderes University Research Fund (project number: VTF14017). Another part of this study was published in Kafkas Univ Vet Fak 2017; 23: 101 and published as meeting abstract (PC049) in Acta Physiologica (2016; 218: 44-44). The authors would like to thank Amanda Chilaka for her kind help in careful proofreading of this manuscript.
dc.identifier.doi10.1556/2060.105.2018.4.25
dc.identifier.endpage324
dc.identifier.issn2498-602X
dc.identifier.issue4
dc.identifier.pmid30565473
dc.identifier.scopus2-s2.0-85059236402
dc.identifier.scopusqualityQ2
dc.identifier.startpage309
dc.identifier.urihttps://doi.org/10.1556/2060.105.2018.4.25
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21910
dc.identifier.volume105
dc.identifier.wosWOS:000454451500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAkademiai Kiado Zrt
dc.relation.ispartofPhysiology International
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectoxidative stress
dc.subjectswimming exercise
dc.subjectprobiotic
dc.subjectcolon morphology
dc.subjectcolon contractility
dc.titleThe effects of exhaustive swimming and probiotic administration in trained rats: Oxidative balance of selected organs, colon morphology, and contractility
dc.typeArticle

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