Effects of incremental peritoneal dialysis with low glucose-degradation product neutral pH solution on clinical outcomes

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dc.authoridTunca, Onur/0000-0003-1958-7617
dc.contributor.authorYeter, Hasan Haci
dc.contributor.authorAltunok, Murat
dc.contributor.authorCankaya, Erdem
dc.contributor.authorYildirim, Saliha
dc.contributor.authorAkturk, Serkan
dc.contributor.authorBakirdogen, Serkan
dc.contributor.authorAkoglu, Hadim
dc.date.accessioned2025-01-27T20:49:58Z
dc.date.available2025-01-27T20:49:58Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose Incremental peritoneal dialysis (IPD) could decrease unfavorable glucose exposure results and preserve (RKF). However, there is no standardization of dialysis prescriptions for patients undergoing IPD. We designed a prospective observational multi-center study with a standardized IPD prescription to evaluate the effect of IPD on RKF, metabolic alterations, blood pressure control, and adverse outcomes. Methods All patients used low GDP product (GDP) neutral pH solutions in both the incremental continuous ambulatory peritoneal dialysis (ICAPD) group and the retrospective standard PD (sPD) group. IPD patients started treatment with three daily exchanges five days a week. Control-group patients performed four changes per day, seven days a week. Results A total of 94 patients (47 IPD and 47 sPD) were included in this study. The small-solute clearance and mean blood pressures were similar between both groups during follow-up. The weekly mean glucose exposure was significantly higher in sPD group than IPD during the follow-up (p < 0.001). The patients with sPD required more phosphate-binding medications compared to the IPD group (p = 0.05). The rates of peritonitis, tunnel infection, and hospitalization frequencies were similar between groups. Patients in the sPD group experienced more episodes of hypervolemia compared to the IPD group (p = 0.007). The slope in RKF in the 6th month was significantly higher in the sPD group compared to the IPD group (65% vs. 95%, p = 0.001). Conclusion IPD could be a rational dialysis method and provide non-inferior dialysis adequacy compared to full-dose PD. This regimen may contribute to preserving RKF for a longer period.
dc.identifier.doi10.1007/s11255-024-04077-7
dc.identifier.endpage3132
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue9
dc.identifier.pmid38740705
dc.identifier.scopus2-s2.0-85193025100
dc.identifier.scopusqualityQ2
dc.identifier.startpage3123
dc.identifier.urihttps://doi.org/10.1007/s11255-024-04077-7
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25371
dc.identifier.volume56
dc.identifier.wosWOS:001221506800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectIncremental peritoneal dialysis
dc.subjectResidual kidney function
dc.subjectPeritoneal glucose exposure
dc.titleEffects of incremental peritoneal dialysis with low glucose-degradation product neutral pH solution on clinical outcomes
dc.typeArticle

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