The acute effects of preoperative ozone theraphy on surgical wound healing

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dc.contributor.authorŞahin, Hasan
dc.contributor.authorŞimşek, Tuncer
dc.contributor.authorTürkon, Hakan
dc.contributor.authorKalkan, Yıldıray
dc.contributor.authorÖzkul, Faruk
dc.contributor.authorÖzkan, M. Turgut Alper
dc.contributor.authorErbaş, Mesut
dc.date.accessioned2025-01-27T20:34:46Z
dc.date.available2025-01-27T20:34:46Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPURPOSE: To investigate the effects of preoperative rectal ozone insufflation on surgical wound healing over the proinflammatory cytokines and histopathological changes. METHODS: Twenty one rabbits were divided into 3 groups Sham, surgical wound, and ozone applied (6 sessions, every other day 70 mu g/mL in 12 mL O2-O3 mixture rectally) surgical wound groups were created. TNF-alpha and IL-6 levels from all rabbits were studied at the basal, 24th hour, and 72nd hour. The histopathological examination was done by removing the surgical scar tissue at the end of 72nd hour. RESULTS: TNF-alfa and IL-6 levels were significantly lower compared to the control group, in the rabbits treated with ozone. The increase in angiogenesis, the decrease in the number of inflammatory cells, epidermal and dermal regeneration, better collagen deposition, and increased keratinisation in stratum corneum were observed in the histopathological examination It was determined that the wound healing noticeably accelerated in the ozone group. CONCLUSION: Preoperative rectal ozone insufflation had a positive effect on surgical wound healing in acute period.
dc.identifier.doi10.1590/S0102-865020160070000007
dc.identifier.endpage478
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue7
dc.identifier.pmid27487282
dc.identifier.scopus2-s2.0-84979743519
dc.identifier.scopusqualityQ2
dc.identifier.startpage472
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160070000007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23458
dc.identifier.volume31
dc.identifier.wosWOS:000380801700007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectOzone
dc.subjectWound Healing
dc.subjectRabbits
dc.titleThe acute effects of preoperative ozone theraphy on surgical wound healing
dc.typeArticle

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