Comparison of Hydroxyethyl starch 130/0.4 (6%) with commonly used agents in an experimental Pleurodesis model

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dc.authoridKapicibasi, Hasan Oguz/0000-0001-7275-1039
dc.contributor.authorKapicibasi, Hasan Oguz
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorGok, Nazli Demir
dc.date.accessioned2025-01-27T20:14:49Z
dc.date.available2025-01-27T20:14:49Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Hydroxyethyl Starch (HES) 130/0.4 (6%) is a commonly used intravascular volume expander with anti-inflammatory and antioxidant properties. In this study, we aimed to compare the histopathologic activity of HES 130/0.4 (6%) with various widely-used agents in pleurodesis. Methods: Forty male Wistar-Albino rats were divided into five groups: controls, povidone-iodine recipients (PI group), sterile talcum recipients (Talcum group), autologous blood recipients (AB group) and HES 130/0.4 (6%) recipients (HES group). Thirty days after application of agents, pleural and lung tissues were resected. Evaluation was performed via macroscopic scoring (adhesion) and specimens were stained with H&E for microscopic examination (inflammation and fibrosis). Results: HES recipients had significantly higher adhesion compared to controls (lower grade 0, higher grade 1 frequency vs. controls), they were found to have significantly lower frequency of grade 2 adhesion (vs. PI, Talc and AB) and grade 3 adhesion (vs. AB), indicating that the adhesion-generating properties of HES were only superior to the control group. HES recipients had significantly higher inflammatory grades compared to controls (lower grade 0, higher grade 1 frequency), while they had lower grades compared to the PI, Talc and AB groups. Although the PI, Talc and AB groups were statistically similar in most comparisons, we observed a trend towards higher success with the use of Talc and especially AB. Conclusion:Our results do not support a role for HES in pleurodesis. We believe that the autologous blood method remains as an effective and successful procedure without side effects.
dc.description.sponsorshipCanakkale Onsekiz Mart Universitesi Bilimsel Arasatirma Projeleri (COMU BAP) Coordination Unit [THD-2018-2763]
dc.description.sponsorshipThis research was supported by Canakkale Onsekiz Mart Universitesi Bilimsel Arasatirma Projeleri (COMU BAP) Coordination Unit with a grant code of THD-2018-2763. There is no role of the funding body in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
dc.identifier.doi10.1186/s12890-020-01260-1
dc.identifier.issn1471-2466
dc.identifier.issue1
dc.identifier.pmid32854677
dc.identifier.scopus2-s2.0-85090018578
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12890-020-01260-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21207
dc.identifier.volume20
dc.identifier.wosWOS:000566498600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofBmc Pulmonary Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectParietal-visceral pleura
dc.subjectPleurodesis
dc.subjectHydroxyethyl starch
dc.titleComparison of Hydroxyethyl starch 130/0.4 (6%) with commonly used agents in an experimental Pleurodesis model
dc.typeArticle

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