Classic Kaposi's sarcoma: A review of 156 cases

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dc.contributor.authorCetin, Bulent
dc.contributor.authorAktas, Bilge
dc.contributor.authorBal, Oznur
dc.contributor.authorAlgin, Efnan
dc.contributor.authorAkman, Tulay
dc.contributor.authorKoral, Lokman
dc.contributor.authorKaplan, Mehmet Ali
dc.date.accessioned2025-01-27T20:50:03Z
dc.date.available2025-01-27T20:50:03Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Kaposi's sarcoma (KS) is a reactive, multifocal, multicentric, angiogenic neoplastic proliferation that is thought to originate from endothelial cells that are infected with human herpesvirus-8 (HHV-8). This report examines a cohort of patients with classic Kaposi's sarcoma (KS) evaluated at the national institute of oncology over the 13-year period. Methods: A retrospective analysis of 156 patients with classic KS, between January 2000 and November 2013, was performed. This study focused on the clinical presentation, staging, diagnosis, and treatment of classic KS. Results: One hundred fifty-six patients (median age 69 and 115 male) were enrolled into the study. Median age at diagnosis was 69 (range: 32e95 years). Male/female ratio was 2.80. The most common location was the lower limbs. There were 75 stage I patients (48.1%), 8 stage II patients (22.4%), 31 stage III patients (19.9%) and 15 stage IV patients (9.6%). Surgery was the most common local treatment method (43%). 44 patients (28.2%) received radiotherapy (RT) at diagnosis. Cytotoxic treatment with chemotherapy or interferon-a was administered in 57 patients. Visceral involvement was observed in 10 patients (lung: nine patients, liver: one patient) and bone metastasis occurred in two patients at relapse. Conclusion: This study is one of the largest reported series. Further studies are required and it will be important to standardize the assessment of disease activity and clinical response. Copyright (C) 2018, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC.
dc.identifier.doi10.1016/j.dsi.2018.06.005
dc.identifier.endpage189
dc.identifier.issn1027-8117
dc.identifier.issn2223-330X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85049434102
dc.identifier.scopusqualityQ2
dc.identifier.startpage185
dc.identifier.urihttps://doi.org/10.1016/j.dsi.2018.06.005
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25395
dc.identifier.volume36
dc.identifier.wosWOS:000451077200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Taiwan
dc.relation.ispartofDermatologica Sinica
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectClassic Kaposi's sarcoma
dc.subjectRadiotherapy
dc.subjectSurgery
dc.subjectChemotherapy
dc.titleClassic Kaposi's sarcoma: A review of 156 cases
dc.typeReview Article

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