Sensitive voltammetric determination of oxymetazoline hydrochloride at a disposable electrode
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this work, sensitive voltammetric determination of oxymetazoline based on its oxidation has been described at a cheap, disposable, and easily prepared pre-treated pencil graphite electrode. The recorded cyclic voltammograms proved that the oxidation response of oxymetazoline goes linearly in the concentration range between 0.25 and 500 µM. The limit of detection and sensitivity of the sensor were found as 0.08 µM and 256.0 µA mM−1 cm−2, respectively. The obtained results confirmed that applied pre-treatment procedure on pencil graphite electrode provides a high voltammetric response and sensitivity towards determination of oxymetazoline. The results (0.0496% ± 0.0003 oxymetazoline) from the real sample studies on a nasal drop (including 0.05% oxymetazoline) indicated that the designed sensor has a high potential for selective, accurate, and sensitive determination of oxymetazoline in pharmaceutical samples.
Açıklama
Anahtar Kelimeler
Electrochemistry, Oxymetazoline, Pencil graphite electrode, Pharmaceutical analysis, Sensors, Voltammetry
Kaynak
Monatshefte fur Chemie
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
152
Sayı
12
Künye
Güneş, M., Karakaya, S., Kocaağa, T., Yıldırım, F., & Dilgin, Y. (2021). Sensitive voltammetric determination of oxymetazoline hydrochloride at a disposable electrode. Monatshefte Für Chemie - Chemical Monthly, 152(12), 1505–1513. https://doi.org/10.1007/s00706-021-02862-z
