Investigation of the effect of ghrelin on bone fracture healing in rats

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dc.authorid0000-0002-7111-6831en_US
dc.authorscopusid57195618686en_US
dc.authorwosid-en_US
dc.contributor.authorErener, Tamer
dc.contributor.authorCeritoglu, Kubilay Uğurcan
dc.contributor.authorAktekin, Cem Nuri
dc.contributor.authorDalgıç, Ali Deniz
dc.contributor.authorKeskin, Dilek
dc.contributor.authorGeneci, Ferhat
dc.contributor.authorOcak, Mert
dc.contributor.authorBilecenoglu, Burak
dc.contributor.authorHücümenoğlu, Sema
dc.contributor.authorÇaydere, Muzaffer
dc.contributor.authorSenes, Mehmet
dc.contributor.authorSezgin, Özge
dc.date.accessioned2023-03-14T11:27:13Z
dc.date.available2023-03-14T11:27:13Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractGhrelin is known to have effects on proliferation and differentiation of osteoblasts and improvement of bone mineral density in rats. However, no experimental research on ghrelin's effects on fracture healing has been reported. In this context, the effect of ghrelin on the union of femoral shaft fractures was examined in this study by evaluating whether ghrelin will directly contribute to fracture healing. Forty male Wistar-Albino rats were divided into two groups as control and experimental (ghrelin treated) and standard closed shaft fractures were created in the left femurs of all rats. Daily ghrelin injections were applied to the experimental groups and equal numbers of rats were killed after 14 and 28 days following fracture formation. Tissue samples were examined with radiological, biomechanical, biochemical and histological analyses. Densitometry study showed that bone mineral density was improved after 28 days of ghrelin treatment compared to control. On histological examination, at the end of the 14 and 28 days of recovery, significant union was observed in the ghrelin-treated group. The ghrelin-treated group had higher breaking strength and stiffness at the end of 28 days of recovery. Biochemically, ALP levels were found to be higher in the ghrelin-treated group at the end of 28 days of recovery. Results showed that ghrelin directly contributes to fracture healing and it is promising to consider the effect of ghrelin on fracture healing in human studies with pharmacological applications.en_US
dc.identifier.citationErener, T., Ceritoğlu, K. U., Aktekin, C. N., Dalgic, A. D., Keskin, D., Geneci, F., . . . Sezgin, Ö. (2021). Investigation of the effect of ghrelin on bone fracture healing in rats. Clinical and Experimental Pharmacology and Physiology, 48(10), 1382-1390. doi:10.1111/1440-1681.13544en_US
dc.identifier.doi10.1111/1440-1681.13544
dc.identifier.endpage1390en_US
dc.identifier.issn0305-1870
dc.identifier.issn1440-1681
dc.identifier.issue10en_US
dc.identifier.pmid34152642
dc.identifier.scopus2-s2.0-85109103610
dc.identifier.startpage1382en_US
dc.identifier.urihttps://doi.org/10.1111/1440-1681.13544
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3810
dc.identifier.volume48en_US
dc.identifier.wosWOS:000669714900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCeritoglu, Kubilay Uğurcan
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiology (CEPP)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Remodellingen_US
dc.subjectFracture Healingen_US
dc.subjectFracture Repairen_US
dc.subjectGhrelinen_US
dc.titleInvestigation of the effect of ghrelin on bone fracture healing in rats
dc.typeArticle

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