Serum H-FABP levels in patients with hypothyroidism

Basit Öğe Kaydı
dc.authoridUkinc, KUBILAY/0000-0002-4727-7432
dc.authoridAsik, mehmet/0000-0002-0716-0221
dc.contributor.authorGunes, Fahri
dc.contributor.authorAsik, Mehmet
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorVural, Ahmet
dc.contributor.authorSen, Hacer
dc.contributor.authorBinnetoglu, Emine
dc.contributor.authorBozkurt, Neslihan
dc.date.accessioned2025-01-27T20:11:48Z
dc.date.available2025-01-27T20:11:48Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHypothyroidism (HT) has an increased risk for cardiovascular mortality and morbidity due to increased atherosclerosis. Heart-type fatty acid binding protein (H-FABP) is abundant in the cytosol of cardiomyocytes, and transports fatty acids into these cells. Although H-FABP has been shown to increase in several atherosclerotic and inflammatory conditions, there is no literature data indicating an alteration in other atherosclerotic processes such as HT. A total of 39 patients with subclinical hypothyroidism (SCH), 26 patients with overt hypothyroidism (OH), and 29 healthy subjects were enrolled in this study. Carotid artery intima media thickness (CIMT) was measured by high resolution B mode ultrasonography. H-FABP levels, thyroid function test, and biochemical tests of all subjects were measured. The associations between H-FABP and thyroid test and CIMT were examined with correlation and regression analysis. OH patients had higher H-FABP levels (mean, 6.18 +/- A 3.08 ng/mL) than both the SCH (mean, 3.81 +/- A 2.16 ng/mL) and the controls (mean, 2.12 +/- A 1.27 ng/mL) (P < 0.01 and < 0.001, respectively). SCH patients had increased serum H-FABP levels compared with control subjects (P < 0.01). CIMT of both OH and SCH patients was also significantly greater compared with control subjects (both of p < 0.01). H-FABP was significantly and positively correlated with age, systolic blood pressure, thyroid stimulating hormone (TSH) levels, and CIMT, and negatively correlated with fT4 levels. The H-FABP levels retained an independent and positive association with systolic blood pressure, and a negative association with fT4 levels. Serum H-FABP levels progressively increased from the control group to the OH group. This suggests that H-FABP may be an indicator of low-level myocardial damage in HT, especially when used together with CIMT. Decreasing serum fT4 levels seem also to have an effect on H-FABP levels.
dc.identifier.doi10.1007/s00508-014-0612-7
dc.identifier.endpage733
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue21-22
dc.identifier.pmid25234940
dc.identifier.scopus2-s2.0-84938074643
dc.identifier.scopusqualityQ1
dc.identifier.startpage727
dc.identifier.urihttps://doi.org/10.1007/s00508-014-0612-7
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20728
dc.identifier.volume126
dc.identifier.wosWOS:000345704300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHypothyroidism
dc.subjectH-FABP
dc.subjectCarotid intima-media thickness
dc.titleSerum H-FABP levels in patients with hypothyroidism
dc.title.alternativeSerum Heart-type Fatty Acid Binding Protein (H-FABP) Konzentrationen bei Patienten mit Hypothyreose
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu