The Effect of Intraurethral Dexpanthenol on Healing and Fibrosis in Rats With Experimentally Induced Urethral Trauma

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dc.authoridOzcan, Serkan/0000-0002-2459-139X
dc.contributor.authorYardimci, Ibrahim
dc.contributor.authorKarakan, Tolga
dc.contributor.authorResorlu, Berkan
dc.contributor.authorDoluoglu, Omer Gokhan
dc.contributor.authorOzcan, Serkan
dc.contributor.authorAydin, Arif
dc.contributor.authorDemirbas, Arif
dc.date.accessioned2025-01-27T20:45:38Z
dc.date.available2025-01-27T20:45:38Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOBJECTIVE To determine the efficacy of dexpanthenol applied early after urethral trauma for preventing inflammation and spongiofibrosis. MATERIALS AND METHODS Twenty-seven rats were randomized and divided into 3 groups, with 9 rats in each group. The urethras of all rats were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14 days, group I was given 0.9% saline twice a day (control group), group II was given dexpanthenol 500 mg/kg ampules once a day and 0.9% saline once a day, and group III was given dexpanthenol 500 mg/kg ampules twice a day intraurethrally using a 22 ga catheter sheath. On day 15, the penises of the rats were degloved to perform penectomy. RESULTS The mean fibrosis scores were 2.4, 2.2, and 1.4, and mean inflammation scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for inflammation (P = .011); however, the difference for fibrosis was not significant (P = .331). The differences between groups I and III were statistically significantly different both for inflammation and fibrosis (P = .004 and P = .003, respectively). Groups II and III were not different significantly for inflammation (P = .638); however, there was less fibrosis in group III, in which high-dose dexpanthenol was administered. CONCLUSION We showed that dexpanthenol applied early after urethral trauma significantly decreased inflammation and spongiofibrosis. We hope that our study will help to decrease strictures after urethral trauma and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures. (C) 2015 Elsevier Inc.
dc.identifier.doi10.1016/j.urology.2014.09.038
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue1
dc.identifier.pmid25530405
dc.identifier.scopus2-s2.0-84918823188
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.urology.2014.09.038
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24662
dc.identifier.volume85
dc.identifier.wosWOS:000346648500072
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUrology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMitomycin-C
dc.subjectStrictures
dc.subjectEfficacy
dc.subjectSpray
dc.titleThe Effect of Intraurethral Dexpanthenol on Healing and Fibrosis in Rats With Experimentally Induced Urethral Trauma
dc.typeArticle

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