The evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perfusion-gated SPECT

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dc.contributor.authorOzdemir, Semra
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorTan, Yusuf Ziya
dc.contributor.authorCelik, Fatmanur
dc.contributor.authorAkgoz, Semra
dc.date.accessioned2025-01-27T20:52:31Z
dc.date.available2025-01-27T20:52:31Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose Hypertension is one of the most important risk factors for cardiovascular disease. However, hypertension may also result in left ventricular dyssynchrony (LVD) which is characterized by delayed activation of certain ventricular segments leading to uncoordinated contraction. The aim of this study was to evaluate the LVD measured by phase analysis of gated single-photon emission computed tomography (SPECT) imaging in patients with hypertension. Methods We retrospectively reviewed the records of the patients who have referred to our institution for myocardial perfusion imaging (MPI) with a diagnosis of cardiovascular disease. In this study, total of 196 patients (127 females and 69 males, with a mean age of 59.62 +/- 10.27 years) with and without hypertension (123 and 73, respectively) were included. Phase analysis parameters were compared in patients with and without hypertension which are derived using Emory Cardiac Toolbox. Among these 196 patients, 72 had echocardiography results. The findings of echocardiographic and phase analysis were also compared. Student's t test, Kruskal-Wallis, Mann-Whitney U test and Spearman correlation test were used to compare the results. Results There were statistically significant differences in the phase standard deviation (p = 0.005) and histogram bandwidth (p < 0.001) parameters of the phase analysis between the patients with and without hypertension groups, respectively. Furthermore, echocardiographic findings were significantly correlated with the result of the phase analysis. Conclusion This study suggested that routine use of phase analysis-gated SPECT imaging will be beneficial for the diagnosis of LVD.
dc.identifier.doi10.1007/s12149-014-0933-7
dc.identifier.endpage247
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue3
dc.identifier.pmid25427636
dc.identifier.scopus2-s2.0-84939960173
dc.identifier.scopusqualityQ2
dc.identifier.startpage240
dc.identifier.urihttps://doi.org/10.1007/s12149-014-0933-7
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25783
dc.identifier.volume29
dc.identifier.wosWOS:000352278800004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofAnnals of Nuclear Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectLeft ventricular function
dc.subjectTechnetium-99 m
dc.subjectGated SPECT
dc.titleThe evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perfusion-gated SPECT
dc.typeArticle

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