Effects of reduced glutathione on nitric oxide level, total antioxidant and oxidant capacity and adenosine deaminase activity

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dc.authoridAtakisi, Onur/0000-0003-1183-6076
dc.authoriderdogan, hidayet metin/0000-0003-1261-4352
dc.contributor.authorAtakisi, O.
dc.contributor.authorErdogan, H. M.
dc.contributor.authorAtakisi, E.
dc.contributor.authorCitil, M.
dc.contributor.authorKanici, A.
dc.contributor.authorMerhan, O.
dc.contributor.authorUzun, M.
dc.date.accessioned2025-01-27T20:58:24Z
dc.date.available2025-01-27T20:58:24Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study was to determine the effect of exogenous GSH, an important antioxidant containing thiol group, on total antioxidant capacity (TAC) and total oxidant capacity (TOC), adenosine deaminase (ADA), a significant indicator of cellular immunity, and nitric oxide (NO) concentrations in rabbits. Sixteen healthy New Zealand rabbits were divided into 2 groups as control and GSH-treated group. Animals in control group received single intraperitoneal (ip) administration of 0.9% saline. Rabbits in GSH-treated group received reduced L-glutathione (10 mg/kg) (ip). Blood samples were taken from the marginal ear vein 0, 3, 6 and 12 hours after injection. Plasma TAC and NO levels were not statistically different between control and GSH group at 0 and 12 hours. Plasma TAC level was found to be significantly higher (p<0.05) while NO level was found to be significantly lower (p<0.05) in GSH treated group when compared to control group at 3 and 6 hours. Plasma TOC and ADA activity were not statistically different between control and GSH group during experiment. In conclusion, exogenous GSH resulted in an alteration of TAC and NO but not TOC and ADA, so exogenous GSH may be a valuable enhancer of the antioxidant system.
dc.identifier.endpage23
dc.identifier.issn1128-3602
dc.identifier.issue1
dc.identifier.pmid20184085
dc.identifier.scopus2-s2.0-76749085686
dc.identifier.scopusqualityQ2
dc.identifier.startpage19
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26697
dc.identifier.volume14
dc.identifier.wosWOS:000274415700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectTotal antioxidant capacity
dc.subjectTotal oxidant capacity
dc.subjectNitric oxide
dc.subjectAdenosine deaminase
dc.subjectReduced glutathione
dc.subjectRabbit
dc.titleEffects of reduced glutathione on nitric oxide level, total antioxidant and oxidant capacity and adenosine deaminase activity
dc.typeArticle

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