Ultrasensitive voltammetric detection of an antimalarial drug (amodiaquine) at a disposable and low cost electrode

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dc.authoridKarakaya, Serkan/0000-0002-6401-3295
dc.contributor.authorKarakaya, Serkan
dc.contributor.authorKartal, Burcu
dc.contributor.authorDilgin, Yusuf
dc.date.accessioned2025-01-27T20:50:03Z
dc.date.available2025-01-27T20:50:03Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, an ultrasensitive electrochemical determination of an antimalarial drug, amodiaquine (ADQ), was described at a cheap and disposable pencil graphite electrode (PGE) which offers a renewable sensing surface for each measurement. The electrochemical behavior of ADQ was investigated on various carboneous electrodes. Cyclic voltammograms showed that ADQ gives reversible peaks at all electrodes. However, the highest currents for oxidation of ADQ and reduction of the oxidized form of ADQ (ADQ((Ox))) among the carboneous electrodes were obtained in the case of using PGE and these redox couple become more reversible and sharper at PGE than the other electrodes. DP voltammograms also showed that the oxidation peak current of ADQ at PGE is about five times higher than at other electrodes. All these results indicate that bare PGE without any modification exhibits an excellent electrocatalytic activity towards oxidation of ADQ. DP voltammetric studies show a wide linear dynamic range from 1.0 to 200 nM with a detection limit and sensitivity of 0.30 nM and 50 mu A mu M-1, respectively. The recovery of ADQ spiked into some different samples was studied. Obtained recovery values (99.2-102.0%) confirmed that non-modified PGE can be used for the ultrasensitive and accurate electrochemical quantification of ADQ in different samples.
dc.description.sponsorshipScientific Research Coordination Unit of Canakkale Onsekiz Mart University [FBA-2019-3046]
dc.description.sponsorshipThis work was supported by The Scientific Research Coordination Unit of Canakkale Onsekiz Mart University, Project number: FBA-2019-3046.
dc.identifier.doi10.1007/s00706-020-02637-y
dc.identifier.endpage1026
dc.identifier.issn0026-9247
dc.identifier.issn1434-4475
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85086132809
dc.identifier.scopusqualityQ2
dc.identifier.startpage1019
dc.identifier.urihttps://doi.org/10.1007/s00706-020-02637-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25398
dc.identifier.volume151
dc.identifier.wosWOS:000539187200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofMonatshefte Fur Chemie
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectUltrasensitive detection
dc.subjectAmodiaquine
dc.subjectAntimalarial drug
dc.subjectPencil graphite electrode
dc.subjectElectrochemistry
dc.subjectSensors
dc.titleUltrasensitive voltammetric detection of an antimalarial drug (amodiaquine) at a disposable and low cost electrode
dc.typeArticle

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