Synthesis, characterization and evaluation of IPN hydrogels for antibiotic release

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dc.authoridSaraydin, Dursun/0000-0001-7191-510X
dc.contributor.authorEkici, S
dc.contributor.authorSaraydin, D
dc.date.accessioned2025-01-27T20:41:00Z
dc.date.available2025-01-27T20:41:00Z
dc.date.issued2004
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe prepared new ternary interpenetrating polymeric networks (IPN) systems containing chitosan, poly(N-vinylpyrrolidone) and poly(acrylamide) polymers. IPNs were synthesized by radical polymerization of acrylamide monomers in presence of glutaraldehyde (G) and N,N'-methylenebisacrylamide as crosslinkers and the other polymers. These IPNs were named as C-P-A. Glutaraldehyde were used in different concentration to control the network porous of IPNs. Spectroscopic and thermal analyses of these cylindrical shaped IPNs were made with fourier transform infrared spectroscopy analysis, thermogravimetric analysis, and thermomechanical analysis. Swelling studies of IPNs were carried out at pH 1.1 and pH 7.4 at 37degreesC. The swelling and diffusion parameters of IPNs in these solutions were calculated. Amoxicillin as a bioactive species was entrapped to the IPNs during synthesis. In vitro release kinetics of IPNs were investigated. The experimental data of swelling and release studies suggest clearly that the swelling and release process obeys second-order kinetics. The release of the entrapped bioactive species from IPNs depends on the degree of crosslinking of the polymer and pH of the medium at body temperature. We observed that amoxicillin release at pH 1.1 was higher than at pH 7.4. As a result, IPNs-based chitosan with different cross-linker concentration could be promising candidates for formulation in oral gastrointestinal delivery systems.
dc.identifier.doi10.1080/10717540490884804
dc.identifier.endpage388
dc.identifier.issn1071-7544
dc.identifier.issue6
dc.identifier.pmid15736833
dc.identifier.scopus2-s2.0-9644288049
dc.identifier.scopusqualityQ1
dc.identifier.startpage381
dc.identifier.urihttps://doi.org/10.1080/10717540490884804
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23961
dc.identifier.volume11
dc.identifier.wosWOS:000225571900007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofDrug Delivery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectamoxicillin
dc.subjectchitosan
dc.subjectdrug release
dc.subjecthydrogel
dc.subjectinterpenetrating polymeric networks
dc.titleSynthesis, characterization and evaluation of IPN hydrogels for antibiotic release
dc.typeArticle

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