Interleukin-1? biosensors: Emerging analytical approaches for precision diagnostics

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dc.authorid0000-0003-4056-1673
dc.contributor.authorBahaabadi, Zahra Jamalizadeh
dc.contributor.authorMahmoudi, Ali
dc.contributor.authorKarav, Sercan
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2026-02-03T12:02:40Z
dc.date.available2026-02-03T12:02:40Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractInterleukin-1 beta (IL-1 beta) is a pro-inflammatory cytokine secreted by activated immune cells that plays a central role in regulating inflammatory responses and immune signaling. Aberrant IL-1 beta expression is strongly associated with numerous pathological conditions, including autoimmune and inflammatory diseases, cancers, and allergic disorders. Accurate and sensitive quantification of IL-1 beta is therefore critical for early diagnosis, disease monitoring, and therapeutic evaluation. Over the past two decades, significant progress has been made in developing biosensors capable of rapid, precise, and cost-effective IL-1 beta detection. This review critically summarizes recent advancements in electrochemical, optical, and electronic biosensing platforms designed for IL-1 beta measurement. Emphasis is placed on the analytical performance, transduction mechanisms, biorecognition elements, and material innovations that underpin these sensor technologies. Literature published between 2000 and 2024 was systematically analyzed to assess design trends, detection limits, and translational applicability. With continuous improvements in sensitivity, selectivity, and miniaturization, IL-1 beta biosensors are poised to transition from laboratory prototypes to clinically deployable diagnostic tools. These advances highlight the growing potential of biosensor technology in precision medicine and real-time immunological monitoring.
dc.identifier.doi10.1016/j.microc.2025.116704
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-105025542383
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.microc.2025.116704
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34817
dc.identifier.volume220
dc.identifier.wosWOS:001653759700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectInterleukin-1 beta (IL-1 beta)
dc.subjectBiosensors
dc.subjectBiomarker detection
dc.subjectElectrochemical sensing
dc.subjectOptical biosensors
dc.subjectCytokine diagnostics
dc.subjectInflammatory diseases
dc.titleInterleukin-1? biosensors: Emerging analytical approaches for precision diagnostics
dc.typeReview

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