Choroidal Thickness in Mild Autonomous Cortisol Secretion

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dc.contributor.authorCakir, Sezin Dogan
dc.contributor.authorCakir, Akin
dc.contributor.authorOzturk, Feyza Yener
dc.contributor.authorBasmaz, Seda Erem
dc.contributor.authorBatman, Adnan
dc.contributor.authorSaygili, Emre Sedar
dc.contributor.authorErol, Rumeysa Selvinaz
dc.date.accessioned2025-01-27T20:11:58Z
dc.date.available2025-01-27T20:11:58Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: To evaluate the patients with mild autonomous cortisol secretion (MACS) by means of choroidal thickness (CT) and also investigate whether CT may be a diagnostic tool in the management of MACS or not. Methods: Twenty-seven patients with MACS and 25 age -sex -matched healthy controls were enrolled in this cross-sectional comparative study. All the participants underwent CT measurement by using Spectralis optical coherence tomography (Heidelberg Engineering, Heidelberg, Germany) with enhanced deep imaging mode at the subfoveal, 500-1000-1500 mu m nasal and 500-10001500 mu m temporal to the foveola. Results: The groups were similar in terms of spherical equivalence, age and axial lengths. The mean CT was significantly thicker in patients with MACS than controls in all measurement quadrants (p<0.001). There was no significant correlation between CT, size of the adenoma, basal cortisol, 1mg dexamethasone suppression test, salivary cortisol, 24 -hour total urine -free cortisol, ACTH and DHEAS levels. However, 2 mg dexamethasone suppression test results were found to be significantly correlated with CT in temporal 500-1000 and 1500 m quadrants (r=0.436, p=0.023, r=0.443, p=0.021 and r=0.488, p=0.010, respectively). Five (18.5%) eyes had pachychoroid pigment epitheliopathy in the MACS group. Conclusion: CT increases in patients with MACS and those tend to have pachychoroid pigment epitheliopathy more frequent than healthy individuals. A thicker choroid in the patients with MACS may be a novel biomarker both as a diagnostic tool for the degree of hypercortisolemia and cortisol-related comorbidity.
dc.identifier.doi10.14744/SEMB.2024.12258
dc.identifier.endpage209
dc.identifier.issn1302-7123
dc.identifier.issn1308-5123
dc.identifier.issue2
dc.identifier.pmid39021683
dc.identifier.startpage204
dc.identifier.urihttps://doi.org/10.14744/SEMB.2024.12258
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20798
dc.identifier.volume58
dc.identifier.wosWOS:001265092600006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofMedical Bulletin of Sisli Etfal Hospital
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectChoroidal thickness
dc.subjectmild autonomous cortisol secretion
dc.subjectoptical coherence tomography
dc.subjectpossible autonomous cortisol secretion
dc.titleChoroidal Thickness in Mild Autonomous Cortisol Secretion
dc.typeArticle

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