Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease

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dc.authoridbagci, binnur/0000-0003-1323-3359
dc.authoridSari, Ismail/0000-0003-3732-2102
dc.contributor.authorYilmaz, Meral
dc.contributor.authorSari, Ismail
dc.contributor.authorBagci, Binnur
dc.contributor.authorGumus, Erkan
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:20:41Z
dc.date.available2025-01-27T20:20:41Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction. It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C>T) influences the aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. We aimed to investigate whether there is an effect of CYP11B2 -344C>T polymorphism on the development of CKD in a Turkish population. Material and Methods. A total of 240 patients with stage 5 CKD and 240 age- and sex-matched healthy individuals were included in the study. Genotyping of CYP11B2 gene -344 T>C promoter polymorphism was carried out using polymerase chain reaction and restriction fragment length polymorphism methods. Results. No significant differences were found in the genotype distribution of CYP11B2 -344 C>T polymorphism between the patients and controls; however, -344 C>T polymorphism was significantly more frequent among the CKD patients with diabetes mellitus as compared to those with it (P = .02). Diabetic CKD patients with TC genotype had a 2-fold increased risk for development of the disease than the CKD patients without diabetes mellitus (odds ratio, 2.21; 95% confidence interval, 1.04 to 4.67). Conclusions. Our study suggests that the CYP11B2 gene -344 C>T polymorphism may have an effect on the development of CKD in diabetic patients.
dc.identifier.endpage214
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue3
dc.identifier.pmid25957425
dc.identifier.scopus2-s2.0-84928989713
dc.identifier.scopusqualityQ3
dc.identifier.startpage209
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21785
dc.identifier.volume9
dc.identifier.wosWOS:000355275200007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIranian Soc Nephrolgy
dc.relation.ispartofIranian Journal of Kidney Diseases
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectaldosterone synthase gene
dc.subjectchronic kidney disease
dc.subjectgene polymorphism
dc.titleAldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease
dc.typeArticle

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