Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score

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dc.authorid0000-0002-5472-3728en_US
dc.authorid0000-0001-7233-8340en_US
dc.authorscopusid57221816994en_US
dc.authorscopusid35222877500en_US
dc.authorwosidEDE-4862-2022en_US
dc.authorwosidERV-1907-2022en_US
dc.contributor.authorUlusoy, M. Hakan
dc.contributor.authorÇırak, Yalçın
dc.contributor.authorAdalı, Yasemen
dc.date.accessioned2022-11-18T12:37:01Z
dc.date.available2022-11-18T12:37:01Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractLipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and to evaluate the relationship between its expression level and clinicopathologic parameters including response to docetaxel treatment, Gleason score, progression-free survival (PFS), and overall survival (OS). We retrospectively analyzed paraffin-embedded tissue sections from 33 metastatic castrate-resistant prostate cancer (mCRPC) patients whose clinical outcomes had been tracked after docetaxel treatment. The expression status of lipocalin-2 was defined by immunohistochemistry (IHC) using the anti-lipocalin-2 antibody. Lipocalin-2 was highly expressed in 36% of the examined specimens. There was no significant correlation between high lipocalin-2 expression and docetaxel response (p:0.09). High lipocalin-2 expression was signi?cantly associated with a higher Gleason score (p=0.027). Kaplan-Meier survival analysis failed to show a significant correlation between expression levels of lipocalin-2 and both OS and PFS although patients with high lipocalin-2 levels had a numerically shorter PFS and OS time compared to patients with low levels. Consequently, it is clear that further studies are needed to evaluate the predictive and prognostic role of lipocalin-2 in prostate cancer patients.en_US
dc.identifier.citationUlusoy, M. H., Cirak, Y., & Adali, Y. (2021). Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score. Prostate Cancer, 2021, 1–6. https://doi.org/10.1155/2021/8836043en_US
dc.identifier.doi10.1155/2021/8836043
dc.identifier.endpage6en_US
dc.identifier.issn2090-3111
dc.identifier.issn2090-312X
dc.identifier.pmid33542838
dc.identifier.scopus2-s2.0-85100319319
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1155/2021/8836043
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3746
dc.identifier.volume2021en_US
dc.identifier.wosWOS:000616133900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUlusoy, M. Hakan
dc.institutionauthorÇırak, Yalçın
dc.language.isoen
dc.publisherHindawien_US
dc.relation.ispartofProstate Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProstateen_US
dc.subjectLipocalin-2en_US
dc.subjectPredictiveen_US
dc.titlePredictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score
dc.typeArticle

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