Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-? G238A and G308A polymorphism?
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Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Termedia Publishing House Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor alpha (TNF-alpha) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time. Aim: To evaluate genetic variations in the TNF-alpha region and its association with psoriasis and related comorbidities. Material and methods: The study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-alpha G308A and G238A polymorphisms by real-time polymerase chain reaction melting-curve analysis and results were compared statistically. Results: Psoriatic patients with both TNF-alpha-298 and TNF-alpha-308 polymorphisms showed no statistically significant increase in the risk of hypertension (OR = 0.425, chi(2) = 1.76, p = 0.18 and OR = 1.87, chi(2) = 1.33, p = 0.25), coronary artery disease (OR = 1.97, chi(2) = 1.91, p = 0.17 and OR = 2.63, chi(2) = 1.35, p = 0.25), or diabetes (OR = 1.35, chi(2) = 0.24, p= 0.62 and OR = 1.53, chi(2) = 0.24, p = 0.62). Conclusions: The current preliminary results suggested that there was no correlation between TNF-alpha promoter polymorphism and diabetes, hypertension and cardiac disease among psoriatic patients in the Turkish population.
Açıklama
Anahtar Kelimeler
psoriasis, diabetes, hypertension, tumor necrosis factor alpha, G298A, G308A
Kaynak
Postepy Dermatologii I Alergologii
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
33
Sayı
6
