Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups

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dc.authoridHIZ, Meliha Merve/0000-0003-4303-9717
dc.contributor.authorHiz, Meliha M.
dc.contributor.authorKilic, Sevilay
dc.contributor.authorIsik, Selda
dc.contributor.authorOgretmen, Zerrin
dc.contributor.authorSılan, Fatma
dc.date.accessioned2025-01-27T20:58:03Z
dc.date.available2025-01-27T20:58:03Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients. The aim of the study: To explore the association of a STAT4 rs7574865 polymorphism to autoimmune thyroid diseases in the general Turkish population and psoriatic subgroups. Material and methods: A total of 132 psoriatic patients and 118 non-psoriatic volunteers were genotyped for STAT4 rs7574865 using real time PCR. Twenty-four of the psoriatic patients and 15 of the non-psoriatic volunteers have autoimmune-related thyroid diseases. Results: The prevalence of the T allele [OR = 4.37; 95% CI: 1.05-19; p = 0.03] of the STAT4 rs7574865 was higher in individuals with autoimmune-related thyroid diseases among the all non-psoriatic volunteers. The volunteers with autoimmune-related thyroid diseases has an increased allele positivity and carriers having at least one of the risk allele was significantly higher than in counterparts with a GG wild genotype [ORGT/TT vs. GG: 1.73; 95% CI: 0.09-32; p = 0.03]. Yet, there was no evidence of an association between rs7574865 and autoimmune-related thyroid disease in psoriatic patients. Conclusions: The STAT4 rs7574865 polymorphism increases autoimmune-related thyroid disease susceptibility among the general population but not in psoriatic patients.
dc.identifier.doi10.5114/ceji.2015.57146
dc.identifier.endpage441
dc.identifier.issn1426-3912
dc.identifier.issn1644-4124
dc.identifier.issue4
dc.identifier.pmid26862307
dc.identifier.scopus2-s2.0-84983108471
dc.identifier.scopusqualityQ3
dc.identifier.startpage437
dc.identifier.urihttps://doi.org/10.5114/ceji.2015.57146
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26593
dc.identifier.volume40
dc.identifier.wosWOS:000368866400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofCentral European Journal of Immunology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectpsoriasis
dc.subjectpolymorphism
dc.subjectSignal transducer and activator of transcription 4 (STAT4)
dc.subjectautoimmune disease
dc.subjectJAK/STAT
dc.subjectautoimmune thyroiditis
dc.subjectrs7574865
dc.titleContribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups
dc.typeArticle

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