Carotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study

Basit Öğe Kaydı
dc.authoridDeniz, Sami/0000-0002-8328-295X
dc.authoridLAKADAMYALI, Huseyin/0000-0002-3036-6770
dc.authoridSengul, Aysun/0000-0002-8084-1322
dc.authoridOgan, Nalan/0000-0001-5232-3803
dc.authoridOzdemir, Ozer/0000-0002-8884-0682
dc.authoridKosar, Filiz/0000-0001-5707-2716
dc.authoridCoskun Beyan, Ayse/0000-0002-3731-2978
dc.contributor.authorGulbas, Gazi
dc.contributor.authorTuran, Onur
dc.contributor.authorSarioglu, Nurhan
dc.contributor.authorDiken, Ozlem Ercen
dc.contributor.authorOgan, Nalan
dc.contributor.authorKadioglu, Esra Ekbic
dc.contributor.authorKurtipek, Ercan
dc.date.accessioned2025-01-27T20:20:09Z
dc.date.available2025-01-27T20:20:09Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Carotid intima-media thickness (CIMT) is a noninvasive method assessing atherosclerosis. Objective It was aimed to determine relationship and survival between COPD and CIMT. Methods CIMT was measured using Doppler ultrasound (USG) in 668 stable COPD patients at 24 centers. Patients were followed-up for 2 years. Results There were 610 patients who completed the study. There were 200 patients CIMT with <0.78 mm (group 1), and 410 with CIMT >= 0.78 mm (group 2). There was a significant difference at the parameters of age, gender, smoking load, biomass exposure, GOLD groups and degree of airway obstruction (FEV1) between groups 1 and 2. Our results revealed positive correlations between mean CIMT and age, smoking load (pack-years), biomass exposure (years), exacerbation rate (last year), duration of hypertension (years) and cholesterol level; negative correlations between CIMT and FEV1 (P < 0.05). According to logistic regression model, compared with group A, risk of CIMT increase was 2.2-fold in group B, 9.7-fold in group C and 4.4-fold in group D (P < 0.05). Risk of CIMT increase was also related with cholesterol level (P < 0.05). Compared with infrequent exacerbation, it was 2.8-fold in the patients with frequent exacerbation (P < 0.05). The mean survival time was slightly higher in group 1, but not significant (23.9 vs 21.8 months) (P > 0.05). Conclusion This study is the first regarding CIMT with combined GOLD assessment groups. It has revealed important findings supporting the increase in atherosclerosis risk in COPD patients. We recommend Doppler USG of the carotid artery in COPD patients at severe stages.
dc.identifier.doi10.1111/crj.13024
dc.identifier.endpage399
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue6
dc.identifier.pmid30942958
dc.identifier.scopus2-s2.0-85066013688
dc.identifier.scopusqualityQ3
dc.identifier.startpage391
dc.identifier.urihttps://doi.org/10.1111/crj.13024
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21587
dc.identifier.volume13
dc.identifier.wosWOS:000470921200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcarotid intima-media
dc.subjectCOPD
dc.subjectexacerbation
dc.subjectsurvival
dc.titleCarotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu