Effects of one year simvastatin and atorvastatin treatments on acute phase reactants in uncontrolled type 2 diabetic patients

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dc.authoridUkinc, KUBILAY/0000-0002-4727-7432
dc.contributor.authorUkinc, Kubilay
dc.contributor.authorErsoz, Halil Onder
dc.contributor.authorErem, Cihangir
dc.contributor.authorHacihasanoglu, Arif Bayram
dc.contributor.authorKarti, Suleyman Sami
dc.date.accessioned2025-01-27T20:22:56Z
dc.date.available2025-01-27T20:22:56Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractType 2 diabetes mellitus is the leading cause of macrovascular diseases and related death. Additionally, diabetes mellitus is frequently complicated by other cardiovascular risk factors, such as hypercholesterolemia, hypertension, obesity, hypercoagulability, and inflammation. We wanted to evaluate and compare the effects of treating with a one-year course of atorvastatin or simvastatin on inflammatory markers such as high sensitive C-reactive protein (hsCRP), fibrinogen, and ferritin in uncontrolled type 2 diabetic patients. Also, we planned to investigate the correlation between inflammatory markers and metabolic parameters. Fifty type 2 diabetic patients (30 women, 20 men; mean age: 49.9 +/- A 8.5 years) were enrolled into the study. Twenty healthy subjects, matched on body mass index and age, were also included in the study as a control group. Diabetic patients were divided into two groups and received simvastatin or atorvastatin (Group S and A, respectively). After 1 year of statin treatment (Group A), there were significant decreases in total cholesterol (217.3 +/- A 46.5-173.8 +/- A 37.2 mg/dl; P < 0.0001), LDL-cholesterol (146.7 +/- A 50.3-102.3 +/- A 31.1 mg/dl, P < 0.0001), hsCRP (0.88 +/- A 0.62-0.35 +/- A 0.18 mg/dl, P < 0.0001), fibrinogen (258.2 +/- A 16.9-215.5 +/- A 10.6 mg/l; P < 0.0001), and ferritin (118.2 +/- A 73.9-81.2 +/- A 72.5 ng/ml, P < 0.0001) levels compared to basal values. In the S group, there were significant decreases in total cholesterol (224.4 +/- A 61.2-175.0 +/- A 47.8 mg/dl; P < 0.0001), LDL-cholesterol (140.9 +/- A 56.7-110.9 +/- A 42.2 mg/dl, P < 0.0001), hsCRP (0.98 +/- A 1.3-0.46 +/- A 0.25 mg/dl, P < 0.0001), fibrinogen (265.7 +/- A 26.8-222.1 +/- A 20.6 mg/l; P < 0.0001), and ferritin (136.7 +/- A 101.1-85.6 +/- A 32.1 ng/ml, P < 0.0001) levels compared to basal values. At the end of the study, a dagger hsCRP, a dagger fibrinogen, and a dagger ferritin levels were correlated with a dagger LDL (r = 0.42; P = 0.005, with a dagger hsCRP), (r = 0.40; P = 0.008, with a dagger fibrinogen), (r = 0.46; P = 0.002, with a dagger ferritin) and a dagger HDL (r = -0.50; P < 0.0001, with a dagger hsCRP), (r = -0.32; p = 0.042, with a dagger fibrinogen), (r = -0.48; P < 0.0001, with a dagger ferritin) cholesterol levels. Atorvastatin and simvastatin treatments were found to be effective for the control of hypercholesterolemia and resulted in a significant decrease in acute phase reactants in uncontrolled type 2 diabetic patients.
dc.identifier.doi10.1007/s12020-009-9157-3
dc.identifier.endpage388
dc.identifier.issn0969-711X
dc.identifier.issue3
dc.identifier.pmid19259830
dc.identifier.scopus2-s2.0-70149124915
dc.identifier.scopusqualityQ2
dc.identifier.startpage380
dc.identifier.urihttps://doi.org/10.1007/s12020-009-9157-3
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22076
dc.identifier.volume35
dc.identifier.wosWOS:000266476500016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAtorvastatin
dc.subjectSimvastatin
dc.subjectType 2 diabetes
dc.subjectC-reactive protein
dc.subjectFibrinogen
dc.subjectFerritin
dc.titleEffects of one year simvastatin and atorvastatin treatments on acute phase reactants in uncontrolled type 2 diabetic patients
dc.typeArticle

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