Viscum album L. Extracts Protects HeLa Cells against Nuclear and Mitochondrial DNA Damage

Basit Öğe Kaydı
dc.authoridOnay-Ucar, Evren/0000-0003-1152-4881
dc.authoridKandemir, Basak/0000-0003-1909-5778
dc.authoridMertoglu Kamali, Elif/0000-0002-3606-4722
dc.authoridArda, Nazli/0000-0002-1043-5652
dc.authoridEROL, Ozlem/0000-0001-8821-5740
dc.contributor.authorOnay-Ucar, Evren
dc.contributor.authorErol, Ozlem
dc.contributor.authorKandemir, Basak
dc.contributor.authorMertoglu, Elif
dc.contributor.authorKaragoz, Ali
dc.contributor.authorArda, Nazli
dc.date.accessioned2025-01-27T20:51:55Z
dc.date.available2025-01-27T20:51:55Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractViscum album L. is a semiparasitic plant grown on trees and widely used for the treatment of many diseases in traditional and complementary therapy. It is well known that some activities of Viscum album extracts are varied depending on the host trees, such as antioxidant, apoptosis-inducing, anticancer activities of the plant. The aim of the present study is to examine the comparative effects of methanolic extracts of V. album grown on three different host trees (locust tree, lime tree, and hedge maple tree) on H2O2-induced DNA damage in HeLa cells. Oxidative damage in mitochondrial DNA and two nuclear regions was assessed by QPCR assay. The cells were pretreated with methanolic extracts (10 mu g/mL) for 48 h, followed by the treatment with 750 mu M H2O2 for 1 hour. DNA damage was significantly induced by H2O2 while it was inhibited by V. album extracts. All extracts completely protected against nuclear DNA damage. While the extract from lime tree or white locust tree entirely inhibited mitochondrial DNA damage, that from hedge maple tree inhibited by only 50%. These results suggest that methanolic extracts of V. album can prevent oxidative DNA damage, and the activity is dependent on the host tree.
dc.description.sponsorshipResearch Fund of Istanbul University [1462]
dc.description.sponsorshipThis study was supported by the Research Fund of Istanbul University (Project no. 1462).
dc.identifier.doi10.1155/2012/958740
dc.identifier.issn1741-427X
dc.identifier.issn1741-4288
dc.identifier.pmid22988477
dc.identifier.scopus2-s2.0-84867025818
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1155/2012/958740
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25585
dc.identifier.volume2012
dc.identifier.wosWOS:000308790000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofEvidence-Based Complementary and Alternative Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPigment Epithelial-Cells
dc.subjectOxidative Stress
dc.subjectAntioxidant Activity
dc.subjectMistletoe
dc.subjectRepair
dc.subjectCancer
dc.subjectGrowth
dc.subjectTrees
dc.titleViscum album L. Extracts Protects HeLa Cells against Nuclear and Mitochondrial DNA Damage
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu