Synthesis and characterization of drug microspheres containing phosphazene for biomedical applications

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dc.authoridOzay, Hava/0000-0002-4184-7801
dc.contributor.authorOzay, Hava
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:22:47Z
dc.date.available2025-01-27T20:22:47Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, microspheres of trimethoprime (TMP), which is an antibiotic drug, were synthesized in a single step. To synthesize microspheres in various sizes, the amount of TMP was kept constant while mole number of the phosphazene used as crosslinker was reduced. TMP microspheres were synthesized through the precipitation polymerization technique with different mole ratios of crosslinker (1:1, 1:2, 1:3, and 1:6) and characterized by FT-IR, TG, XPS, particle size analysis and SEM-EDX analyses. An in vitro biodegradation test conducted on TMP microspheres in acidic media showed that they degraded at a ratio of 92% in 50 days. In addition, TMP microspheres were used in controlled release of Vitamin B12 and Rhodamine 6G, which had been chosen as model drugs. (C) 2014 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.colsurfa.2014.03.022
dc.identifier.endpage105
dc.identifier.issn0927-7757
dc.identifier.issn1873-4359
dc.identifier.scopus2-s2.0-84897876941
dc.identifier.scopusqualityQ1
dc.identifier.startpage99
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2014.03.022
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22031
dc.identifier.volume450
dc.identifier.wosWOS:000335274200013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofColloids and Surfaces A-Physicochemical and Engineering Aspects
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMicrosphere
dc.subjectDrug release
dc.subjectPhosphazene
dc.subjectTrimethoprime
dc.subjectBiodegradation
dc.titleSynthesis and characterization of drug microspheres containing phosphazene for biomedical applications
dc.typeArticle

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