An experimental study of ascorbic acid effects in acute renal failure under general anesthesia

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dc.authoridGunay, Murat/0000-0002-2079-6654
dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.contributor.authorOzturk, Omur
dc.contributor.authorUstebay, Sefer
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorGunay, Murat
dc.contributor.authorAdali, Yasemen
dc.contributor.authorDonmez, Ilksen
dc.contributor.authorErbas, Mesut
dc.date.accessioned2025-01-27T20:38:55Z
dc.date.available2025-01-27T20:38:55Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycerol on the upper hind limb on the 15th minute of inhalation anesthesia. Biochemical parameters consisted of serum levels of blood urea nitrogen, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), total antioxidant capacity (TAC), and protein carbonyl content. Histopathological variables were tubular necrosis, fibrin, and cast formation. Results: NGAL levels were significantly lower in Group III than Group II and Group I. On the other hand, TAC, PCO, urea and creatinine levels were notably higher in Group I compared with Groups II and III. There was a significant difference between 3 groups on frequencies of acute tubular necrosis (p=0.003), fibrin (p<0.001) and cast (p<0.001). Acute tubular necrosis and fibrin formation were more prominent in Group I. Casts were more common in Groups II and III. Conclusions: The ascorbic acid serve as a prophylactic agent against renal damage in patients receiving sevoflurane anesthesia and higher doses were associated with more apparent protective effects.
dc.identifier.doi10.1590/s0102-865020170100000007
dc.identifier.endpage861
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue10
dc.identifier.pmid29160372
dc.identifier.scopus2-s2.0-85034416089
dc.identifier.scopusqualityQ2
dc.identifier.startpage853
dc.identifier.urihttps://doi.org/10.1590/s0102-865020170100000007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23804
dc.identifier.volume32
dc.identifier.wosWOS:000415347900007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAscorbic Acid
dc.subjectGlycerol
dc.subjectAcute Kidney Injury
dc.subjectAnesthesia
dc.subjectGeneral
dc.subjectRats
dc.titleAn experimental study of ascorbic acid effects in acute renal failure under general anesthesia
dc.typeArticle

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