Can PEI microgels become biocompatible upon betainization?

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorDemirci, Şahin
dc.date.accessioned2025-01-27T20:29:04Z
dc.date.available2025-01-27T20:29:04Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPolyethylene imine (PEI) microgels prepared via micro emulsion polymerization technique were treated with 1,3-propane sultone to obtained betainized PEI (b-PEI) microgels. The betainization reaction generated zwitterions on PEI microgel that are positive charges from quartemized amine groups of PEI, and the newly formed negative charges from SO3- groups from the modifying agent, 1,3-propane sultone offered interesting properties. The smaller size of b-PEI microgels that are obtained by simple filtration were increased with betainization from 512 +/- 14 to 1114 +/- 86 nm. Also, the betainization of PEI microgel provided negative zeta potential values at high pH values as 9, 10, 11, and 12. Moreover, the b-PEI microgels render more effective dye absorption capabilities for anionic or cationic organic dyes such as Methyl Orange (MO) and Methylene Blue (MB) separately with the significant increase dye adsorption capacity of 354 +/- 31 and 274 +/- 19 mg/g respectively. Moreover, antibacterial properties of b-PEI microgels tested on the E. coli ATCC 8739 and S. aureus ATCC 6538 were diminished whereas bare PEI has low MIC and MBC values (strong antibacterial properties). Interestingly, the PEI microgels known for their strong antibacterial and toxic nature found to be biocompatible upon betainization reaction. The biocompatibility test were carried with WST-1 tests and double staining methods. The cytotoxicity, apoptotic and necrotic cell tests were shown that PEI microgels induce no cytotoxicity up to 400 mu g/mL whereas PEI microgels possessed 50% toxicity at this concentration, suggesting that b-PEI microgels become biocompatible upon betainization with, 3-propane sultone. (C) 2017 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.msec.2017.03.285
dc.identifier.endpage648
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid28532075
dc.identifier.scopus2-s2.0-85017164989
dc.identifier.scopusqualityN/A
dc.identifier.startpage642
dc.identifier.urihttps://doi.org/10.1016/j.msec.2017.03.285
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22810
dc.identifier.volume77
dc.identifier.wosWOS:000403381200072
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPEI microgel/nanogels
dc.subjectBetainized PEI microgel/nanogel
dc.subjectPolybetaine microgel/nanogel
dc.subjectBiocompatible PEI microgel/nanogel
dc.titleCan PEI microgels become biocompatible upon betainization?
dc.typeArticle

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