Increased insulin secretion suppresses cortisol levels, exacerbates inflammation and beta-cell dysfunction Increased insulin resistance with cortisol levels and HOMA- beta

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dc.authorid0000-0003-2134-4067en_US
dc.authorscopusid-en_US
dc.authorwosid-en_US
dc.contributor.authorKocatürk, Evin
dc.contributor.authorKar, Ezgi
dc.contributor.authorKiraz, Zeynep Kuşku
dc.contributor.authorAlatas, I. Ozkan
dc.date.accessioned2023-05-15T10:05:04Z
dc.date.available2023-05-15T10:05:04Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractAim: The role of inflammatory mechanisms in the formation of insulin resistance (IR), diabetes and metabolic syndrome has been widely discussed in recent years. The aim of this study was to investigate the relationship between IR and pancreatic β-cell function with hematological inflammatory markers and cortisol levels. Material and Methods: Four hundred fifteen adult patients whose samples were accepted to the laboratory between the hours of 08:00-12:00; leukocyte, neu-trophil and lymphocyte count, mean platelet volume (MPV), insulin, glucose, and cortisol levels were examined retrospectively. The neutrophil-lymphocyte ratio (NLR), the homeostasis model assessment (HOMA)-IR and HOMA-β values were calculated according to the collected data. The patients were divided into two groups: with (HOMA-IR≥2.5) and without IR (HOMA-IR<2.5). All data were statistically evaluated using the SPSS package program. Results: A statistically significant difference was found in cortisol levels (p=0.003), leukocyte (p<0.001), neutrophil (p<0.001), lymphocyte counts (p=0.003) and NLR (p=0.011) between the groups. However, there was no significant difference between the MPV levels. Both HOMA-IR and HOMA-β showed a weak positive correlation with leukocyte, neutrophil and lymphocyte counts and showed a negative correlation with cortisol levels. There was a weak positive correlation between NLR levels and HOMA-IR. Although there was a negative correlation between cortisol with insulin and NLR levels, no significant correlation was found between cortisol and glucose, neutrophil-lymphocyte count. Discussion: The significant increase in hematological inflammatory cells in patients with IR suggests that inflammatory mechanisms may have produced insulin resistance. The increase in insulin levels and suppression of cortisol levels may play a role in the progression of inflammation.en_US
dc.identifier.citationKocatürk, E., Kar, E., Kiraz, Z. K., Alataş, I. Ö. (2021) Increased insulin secretion suppresses cortisol levels, exacerbates inflammation and beta-cell dysfunction Increased insulin resistance with cortisol levels and HOMA- beta. Annals of Clinical and Analytical Medicine, 12(S4), 365-369. doi:10.4328/ACAM.20591en_US
dc.identifier.doi10.4328/ACAM.20591
dc.identifier.endpage369en_US
dc.identifier.issn2667-663X
dc.identifier.issueS4en_US
dc.identifier.startpage365en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4144
dc.identifier.volume12en_US
dc.identifier.wosWOS:000731638200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKar, Ezgi
dc.language.isoen
dc.publisherBayrakol Medical Publishingen_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectInsulin Resistanceen_US
dc.subjectNeutrophilsen_US
dc.subjectLymphocytesen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectHydrocortisoneen_US
dc.titleIncreased insulin secretion suppresses cortisol levels, exacerbates inflammation and beta-cell dysfunction Increased insulin resistance with cortisol levels and HOMA- beta
dc.typeArticle

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