Correlation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion

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dc.authoridYildirim, Sule/0000-0002-1815-808X
dc.contributor.authorYildirim, Ahmet
dc.contributor.authorYildirim, Sule
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorTekin, Mustafa
dc.contributor.authorKucuk, Adem
dc.contributor.authorErdem, Havva
dc.contributor.authorErbas, Mesut
dc.date.accessioned2025-01-27T20:11:57Z
dc.date.available2025-01-27T20:11:57Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: Ischemia modified albumin (IMA) levels significantly increased and may be used as a diagnostic marker in ovarian torsion. The aim of this study is to investigate whether there was any correlation between IMA levels and histopathologic changes in experimental ovarian torsion. Material and methods: Fourteen Sprague-Dawley rats, each weighing 220-250 g were divided randomly into 2 groups; in Group 1, the control group (n = 7), only laparotomy was performed and in Group 2, the experimental group (n = 7), ovarian torsion was performed. Ischemia was performed for 3 h; following the ischemia period, the torsion was relieved by detwisting the adnexa and then the ovarian I/R protocol was applied for 3 h. Blood samples were taken from all of the rats to measure the IMA levels and the ovaries were surgically removed for histologic examination. A blinded pathologist examined and scored the samples. Results: The median (minimum-maximum) IMA values were 921.00 (870.00-966.00) ABSUs in the ovarian torsion group and 853.00 (782.00-869.00) ABSUs in the control group. The difference was statistically significant. In the correlation analysis, a significant and strong correlationwas found between IMA levels and histopathologic changes (Spearman's rho = vertical bar 0.987, p < 0.001). Conclusion: Positive correlation was found between the IMA levels and the histopathologic severity of the disease. This finding is important for both diagnosis of the disease and patient follow-up. As a new marker in ovarian torsion, IMA may also indicate the severity of the ovarian histopathology. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner.
dc.identifier.doi10.1016/j.tjem.2016.02.004
dc.identifier.endpage11
dc.identifier.issn1304-7361
dc.identifier.issue1
dc.identifier.pmid27239631
dc.identifier.scopus2-s2.0-84992512276
dc.identifier.scopusqualityQ2
dc.identifier.startpage8
dc.identifier.urihttps://doi.org/10.1016/j.tjem.2016.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20790
dc.identifier.volume16
dc.identifier.wosWOS:000393518500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofTurkish Journal of Emergency Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectIschemia-modified albumin
dc.subjectOvary
dc.subjectPathology
dc.subjectRats
dc.titleCorrelation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion
dc.typeArticle

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