Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia

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dc.authoridKandis, Hayati/0000-0001-9151-6050
dc.authoridSEZEN, GULBIN/0000-0001-5790-2337
dc.contributor.authorErbas, Mesut
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorYildirim, Hayriye Ak
dc.contributor.authorSezen, Gulbin
dc.contributor.authorIskender, Abdulkadir
dc.contributor.authorKaragoz, Ibrahim
dc.contributor.authorKandis, Hayati
dc.date.accessioned2025-01-27T20:49:44Z
dc.date.available2025-01-27T20:49:44Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and objectives: Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes to the oxidative stress and antioxidative defense mechanisms. This study aims to compare the effects of sevoflurane, desflurane and propofol infusion anesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy. Methods: 45 patients between 18 and 50 years with planned laparoscopic cholecystectomy under general anesthetic were included in the study. Patients were divided into three groups on the way to surgery: propofol (group P n: 15), sevoflurane (group S n: 15) and desfiurane (group D n: 15). All groups were given hypnotic 2 mg/kg propofol IV, 1 mcg/kg fentanyl IV and 0.1 mg/kg vecuronium IV for induction. For maintenance of anesthesia group S were ventilated with 2% sevoflurane, group D cases were given 6% desflurane and group P were given propofol infusions of 12 mg/kg/h for the first 10 min, 9 rrig/kg/h for the second 10 min and 6 mg/kg/h after that. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutation peroxidase, total oxidants and antioxidants. Results and conclusions: The 45 patients included in the study were 22 male and 23 female patients. The demographic characteristics of the groups were similar. In the postoperative period we observed that while sevoflurane and propofol increased antioxidants by a statistically significant level, desfiurane increased the total oxidants level by a significant amount compared to levels before the operation. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
dc.identifier.endpage72
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue1
dc.identifier.pmid25443441
dc.identifier.scopus2-s2.0-84926416070
dc.identifier.scopusqualityN/A
dc.identifier.startpage68
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25294
dc.identifier.volume65
dc.identifier.wosWOS:000348246300011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofRevista Brasileira De Anestesiologia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectOxidant
dc.subjectAntioxidant
dc.subjectPropofol
dc.subjectGeneral anesthesia
dc.titleComparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia
dc.title.alternativeComparação dos efeitos da perfusão de sevoflurano, desflurano e propofol sobre o sistema oxidante/antioxidante durante anestesia geral
dc.typeArticle

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