Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study

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dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.authoridSilva Marques Pinto, Andre/0000-0002-2077-3356
dc.authoridGunst, Jesper/0000-0002-3787-0259
dc.authoridCascio, Antonio/0000-0002-1992-1796
dc.authoridFiliz, Mine/0000-0002-6928-2435
dc.authoridSantos, Lurdes/0000-0002-0622-6823
dc.authoridMeric Koc, Meliha/0000-0002-0563-6900
dc.contributor.authorFiliz, Mine
dc.contributor.authorErdem, Hakan
dc.contributor.authorAnkarali, Handan
dc.contributor.authorPuca, Edmond
dc.contributor.authorRuch, Yvon
dc.contributor.authorSantos, Lurdes
dc.contributor.authorFasciana, Teresa
dc.date.accessioned2025-01-27T20:24:48Z
dc.date.available2025-01-27T20:24:48Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Blood culture-negative endocarditis (BCNE) is a diagnostic challenge, therefore our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study included adult patients with definite endocarditis. Data were collected via the Infectious Diseases International Research Initiative (ID-IRI). The study analysing one of the largest case series ever reported was conducted across 41 centers in 13 countries. We analysed the database to determine the predictors of BCNE using univariate and logistic regression analyses. Results: Blood cultures were negative in 101 (11.65 %) of 867 patients. We disclosed that as patients age, the likelihood of a negative blood culture significantly decreases (OR 0.975, 95 % CI 0.963-0.987, p < 0.001). Additionally, factors such as rheumatic heart disease (OR 2.036, 95 % CI 0.970-4.276, p = 0.049), aortic stenosis (OR 3.066, 95 % CI 1.564-6.010, p = 0.001), mitral regurgitation (OR 1.693, 95 % CI 1.012-2.833, p = 0.045), and prosthetic valves (OR 2.539, 95 % CI 1.599-4.031, p < 0.001) are associated with higher likelihoods of negative blood cultures. Our model can predict whether a patient falls into the culture-negative or culture-positive groups with a threshold of 0.104 (AUC +/- SE = 0.707 +/- 0.027). The final model demonstrates a sensitivity of 70.3 % and a specificity of 57.0 %. Conclusion: Caution should be exercised when diagnosing endocarditis in patients with concurrent cardiac disorders, particularly in younger cases.
dc.identifier.doi10.1016/j.nmni.2024.101453
dc.identifier.issn2052-2975
dc.identifier.pmid39109072
dc.identifier.scopus2-s2.0-85198507092
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.nmni.2024.101453
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22351
dc.identifier.volume60
dc.identifier.wosWOS:001278273400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofNew Microbes and New Infections
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectInfective endocarditis
dc.subjectRheumatic heart disease
dc.subjectProsthetic valves
dc.subjectCardiac disorders
dc.subjectBlood culture negative endocarditis
dc.titleIdentifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study
dc.typeArticle

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