Biodegradable super porous inulin cryogels as potential drug carrier

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridAri, Betül / 0000-0003-3557-3055
dc.contributor.authorAri, Betül
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:22:33Z
dc.date.available2025-01-27T20:22:33Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHere, chemically crosslinked super porous inulin cryogels were synthesized by the cryogelation method using divinyl sulfone (DVS) at various mol ratios of 75% to 150% inulin repeating units. Inulin cryogel prepared at 75 mol% DVS crosslinking showed a maximum swelling capacity of 1842 +/- 159% in phosphate buffer saline (PBS, pH 7.4). The hydrolytic degradation of inulin cryogels prepared at different ratios were investigated at 37.5 degrees Cat pH 1, 7.4, and 9. Depending on the degree of crosslinking, it was found that inulin cryogels were completely degraded in 1 to 6 days at pH 1, and the degradation continued at pH 7.4 and 9 for up to 21 days. Inulin cryogel with 75 mol% crosslinker had 61% +/- 7% and 45% +/- 2% weight losses at pH 7.4 and pH 9, respectively, at end of 21 days. Also, 75% crosslinked inulin cryogel was conjugated with amoxicillin trihydrate (AMX) drug and released 65.15 +/- 5.35 mg/g of AMX at pH 1 at end of 24 hours. At pH 7.4 and 9, the AMX released amount were determined as 64.83 +/- 6.19 and 55.57 +/- 4.00 mg/g, respectively, in 120 hours. Furthermore, inulin cryogels were determined to be blood compatible materials via hemolytic tests with hemolysis ratio of 1.08% +/- 0.14% and a blood clotting index of 80.67% +/- 1.86%.
dc.description.sponsorshipScientific Research Commission of Canakkale Onsekiz Mart University, (COMU BAP) [FYL-2019-2816]
dc.description.sponsorshipThis work was supported by the Scientific Research Commission of Canakkale Onsekiz Mart University, (COMU BAP, FYL-2019-2816). Authors thank to Dr Selin Sagbas Suner for the help in blood compatibility studies.
dc.identifier.doi10.1002/pat.5014
dc.identifier.endpage2873
dc.identifier.issn1042-7147
dc.identifier.issn1099-1581
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85089867527
dc.identifier.scopusqualityQ2
dc.identifier.startpage2863
dc.identifier.urihttps://doi.org/10.1002/pat.5014
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21945
dc.identifier.volume31
dc.identifier.wosWOS:000562600400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPolymers For Advanced Technologies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbiodegradable polymer network
dc.subjectblood compatible drug carrier
dc.subjectinulin cryogel
dc.titleBiodegradable super porous inulin cryogels as potential drug carrier
dc.typeArticle

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