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    İntraüterin inseminasyon uygulanan hastalarda r-FSH ve klomifen sitrat ile ovülasyon indüksiyon sonuçlarının karşılaştırılması: 130 siklusun analizi
    (2013) Hacıvelioğlu, S.; Gencer, M.; Güngör, A. N. Çakır; Uysal, A.; Coşar, E.
    Amaç: İntraüterin inseminasyon (İUİ) uygulanan hastalarda ideal ovülasyon indüksiyon (Oİ) protokolünün hangisi olduğu henüz net olarak bilinmemektedir. Bu retrospektif çalışmanın amacı, İUİ yapılan hastalarda Oİ için kullanılan rekombinan FSH (r-FSH) ve klomifen sitrat (KS)'ın gebelik oranları üzerindeki etkilerini ortaya koymaktır.Gereç ve Yöntem: Taze eş spermi ile İUİ uygulanan 130 siklus retrospektif olarak değerlendirildi. Çalışma iki tedavi grubundan oluştu; birinci gruba r-FSH + İUİ yapılan 35 tedavi siklusu ve ikinci gruba KS+İUİ yapılan 95 tedavi siklusu dahil edildi. Bu iki grup çeşitli klinik ve laboratuar parametreler yönünden karşılaştırıldı.Bulgular: Gebelik oranı r-FSH grubunda %17,1 ve KS grubunda %10,5 olarak saptandı ve aralarında istatistiksel fark bulunmadı (p=0,368). hCG günündeki endometrium (EM), KS grubunda daha ince izlendi (p <0,001). EM kalınlığı 7 mm altında olan hastaların oranı KS grubunda daha fazlaydı (p=0,012). Fakat 7 mm altındaki ve üstündeki EM değerlerinde her iki tedavi grubunda da gebelik oranları istatistiksel olarak benzerdi (p=0,773).Sonuç: KS ile yapılan indüksiyonlara hCG günü EM kalınlığı r-FSH grubuna göre daha ince izlenmekle birlikte, 7 mm altındaki bu ince EM'lerde gebelik oranının değişmediği görüldü. İUİ yapılan hastalarda ovülasyon indüksiyonu için kullanılan r-FSH ve KS'nin gebelik oranları benzer olduğundan, bu hastalarda daha ucuz ve enjeksiyon gerektirmeyen KS tedavisi r-FSH'a karşı etkin bir alternatif olabilir.
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    Öğe
    PREVALENCE AND MUTATIONS OF ?-THALASSEMIA TRAIT AND ABNORMAL HEMOGLOBINS IN PREMARITAL SCREENING IN CANAKKALE PROVINCE, TURKEY
    (Macedonian Acad Sciences Arts, 2016) Uludag, A.; Uysal, A.; Uludag, A.; Ertekin, Y. H.; Tekin, M.; Kutuk, B.; Sılan, Fatma
    The prevalence of beta-thalassemia (beta-thal) carriers in Turkey varies according to region but in general it is 2.0%. Canakkale is a city in the Aegean region of Turkey but no study about beta-thal frequency in Canakkale has been published to date. In this study, we aimed to investigate the frequency of beta-thal mutations in this province. A total of 4452 couples (8904 individuals) applied for premarital thalassemia scans at the Canakkale State Health Directorate Laboratory between January 2008 and June 2012 and scanning was done with high performance liquid chromatography (HPLC). Of 125 beta-thal carriers seen at the Medical Genetics Clinic, Canakkale Onsekiz Mart University, Canakkale, Turkey, for genetic counseling, 46 participated in the study. The remaining 79 patients could not be reached. The prevalence for beta-thal carriers in Canakkale was identified as 1.4% (125/8904). One couple were both beta-thal carriers. beta-Globin gene analysis of 46 carriers found the total frequency of the three most common mutations was 45.6%. These mutations were found to be HBB: c. 93-21G>A [IVS-I-110 (G>A)], 26.08% (12/46); HBB: c. 17_ 18delCT [codon 5 (-CT)], 10.85% (5/46); HBB: c. 20delA [codon 6 (-A)] 8.69% (4/46). This is the first report on the frequency and mutation profiles of beta-thal for Canakkale. The incidence of beta-thal carriers in Canakkale is below the average for Turkey. The most frequently observed mutation profile and rate of beta-thal in our region is different from the other regions of Turkey.
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    Öğe
    Stria gravidarum is genetic but not related with collagen gene polymorphism
    (Gene Therapy and Molecular Biology, 2013) Cakir Gungor, Ayse Nur; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.
    Background: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. Methods: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. Results: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, %95CI 0.36-4.86, p=0.66). Conclusion: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.
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    Öğe
    Stria Gravidarum Is Genetic But Not Related With Collagen Gene Polymorphism
    (Gene Therapy Press, 2013) Gungor, Cakir A. N.; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.
    BACKGROUND: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. METHODS: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. RESULTS: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, % 95CI 0.36-4.86, p= 0.66). CONCLUSION: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.
  • [ X ]
    Öğe
    The effect of maternal polycystic ovary morphology on first-trimester maternal serum biochemical markers of aneuploidy and fetal nuchal translucency thickness
    (Imr Press, 2015) Hacivelioglu, S.; Uysal, A.; Gungor, A. N. Cakir; Gencer, M.; Cakir, D. U.; Cosar, E.
    Objective: To evaluate the effect of maternal polycystic ovary (PCO) morphology on maternal serum free beta-human chorionic gonadotropin (beta-hCG), pregnancy associated plasma protein A (PAPP-A), and nuchal translucency (NT) thickness in the first-trimester. Material and Methods: A total of 92 pregnant women in the first-trimester were included in the study. Of them, 57 had PCO morphology, and 35 women constituted the control group, with apparently normal ovaries. Maternal serum free beta-hCG, PAPP-A, and NT thickness were measured and compared in all patients. Results: The multiples of median (MoM) levels of serum free beta-hCG were significantly higher in the PCO morphology group compared to the normal ovary group (p = 0.024). However, the MoM levels of PAPP-A were similar in both groups (p = 0.947). No difference was found between the groups in terms of fasting glucose levels and NT measurements (p = 0.976 and 0.565, respectively). Conclusion: In pregnancies with maternal PCO morphology, the presence of higher maternal serum free beta-hCG levels may require correction in the calculation of risks related to first-trimester screening for chromosomal abnormalities. Larger studies are needed to confirm our preliminary data.