Stria gravidarum is genetic but not related with collagen gene polymorphism
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gene Therapy and Molecular Biology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. Methods: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. Results: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, %95CI 0.36-4.86, p=0.66). Conclusion: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.
Açıklama
Anahtar Kelimeler
Collagen; Genetic polymorphism; Risk factors; Stretch marks; Stria distensae
Kaynak
Gene Therapy and Molecular Biology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
15
Sayı
1
