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    ANTIOXIDANT ACTIVITIES AND CHEMICAL COMPOSITON OF DIFFERENT EXTRACTS OF MOSSES GATHERED FROM TURKEY
    (Univ Agricultural Sciences & Veterinary Medicine Bucharest, 2017) Yayintas, Ozlem Tonguc; Sogut, Ozlem; Konyalioglu, Sibel; Yilmaz, Selehattin; Tepeli, Burcu
    Recent pharmacological investigations of bryophytes have proven that the active principles present in these plants are quite unique and having potential chemical application and antioxidant capacity. The mosses of Oxytegius tenuirostris, Eurhynchium striatum W. P. Schimper and Rhynchostegium murale (Hedw.) Schimp. were collected from different locations of Turkey, and dried and exracted with different solvents. Volatiles were isolated from the samples by solid phase microextraction. Gas Chromatography- Mass Spectrometry (GC-MS) was used to identify volatile compounds. Antioxidant activities of moss were tested by free radical scavenging activity (DPPH center dot assay), Trolox equivalent (TEAC) and Cupric Reducing Antioxidant Capacity (CUPRAC) methods. Antioxidant activities were found for mossesas 24.67-67.12 mg/g from chloroform extract, 18.83-35.83 mg/g from ethanol extract, 7.78-46.09 mg/g from methanol extract and 12.56-34.13 mg/g from water extract by DPPH center dot assay method. Antioxidan activities were found as 562.07-2060.52 mg/g from chloroform extract, 597.44-1765.77 mg/g from ethanol extract, 2506.23-7454.92 mg/g from methanol extract and 676.41-5631.23 mg/g from water extract by Trolox method. Antioxidant activities were found as 9.78-64.60 mg/g from chloroform extract, 5.62-28.37 mg/g from ethanol extract, 4.23-30.54 mg/g from methanol extract and 4.92-27.77 mg/g from water extract by Cuprac method. On the basis of the results it is suggested that the extract of mosses species determined here could be of use as an easily accessible source of natural antioxidant for the treatment.
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    Öğe
    Moksifloksasin hidroklorür'ün elektrokimyasal özelliklerinden yararlanarak ticari ilaç formlarındaki ve insan idrarına eklenen miktarının belirlenmesi
    (Çanakkale Onsekiz Mart Üniversitesi, 2018) Tepeli, Burcu; Yılmaz, Selehattin
    Moksifloksasin hidroklorürün (MOKHCI) farmasötik preparatlardaki ve insan idrarına eklenen miktarını belirlemek için voltametrik bir yöntem kullanıldı. Elektrokimyasal deneyler, camsı karbon elektrotta (GCE) 0,51-12,00 pH aralığında farklı tampon çözeltilerde dönüşümlü voltametri ve diferansiyel puls voltametri (DPV) teknikleri ile gerçekleştirildi. pH'ın pik potansiyeli ve pik akıma etkisi incelendi. Analitik tayin için fosfat tamponu (pH 6,50) seçildi. Akımın difüzyon kontrollü olduğu tespit edildi. MOKHCl'ün 3x10-4 M – 1,1x10-3 M konsantrasyon aralığında DPV tekniği ile doğrusal bir kalibrasyon eğrisi oluşturuldu. Belirme sınırı (LOD) ve kantitatif tayin sınırı (LOQ) sırasıyla 5,51x10-5 M ve 2,30 x10-4 M olarak bulundu. Uygulanan yöntem valide edildi.
  • [ X ]
    Öğe
    Reduction Behavior of Moxifloxacin Hydrocholaride and Its Analysis in Spiked Human Urine and Dosage Form by Voltammetry
    (2019) Tepeli, Burcu; Yılmaz, Selehattin; Yağmur, Sultan
    Avoltammetric method was developed to analyze moxifloxacin hydrochloride (Mox- HCl) in pharmaceutical preparations and spiked human urine. The experimental measurements were completed using different buffer systems (pH 0.50- 12.05) on Glassy Carbon Electrode (GCE) with differential pulse voltammetry (DPV) and Cyclic Voltammetry (CV) methods. The effect of pH on the peak current and potential were determined. Britton-Robinson (BR) buffer (pH 7.00) was used for analysis. The peak was established to be diffusion-controlled based on the nature of electrode. Calibration plots were prepared for the concentration range from 3×10-4 M to 1.1×10-3 M with DPV. Limits of detection (LOD) and quantification (LOQ) were calculated as 5.1×10-5 M and 2.30×10-4 M, respectively. The validation of the applied methods was completed. Electroreduction mechanism was proposed.