Yazar "MacManus, Stephen M." seçeneğine göre listele

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    Öğe
    Bioactivity of two Turkish endemic Centaurea species, and their major constituents
    (Sociedade Brasileira de Farmacognosia, 2007) Shoeb, Mohammad; MacManus, Stephen M.; Jaspars, Marcel; Kong-Thoo-Lin, Paul; Nahar, Lutfun; Celik, Sezgin; Sarker, Satyajit D.
    The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs, armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays. The reversed-phase HPLC analysis of the methanol extracts afforded two bioactive dibenzylbutyrolactone-type lignans, matairesinoside (1) and arctiin (2). The structures of these lignans were elucidated by comprehensive spectroscopic analyses as well as by the direct comparison of experimental data with respective literature data.
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    Öğe
    Two salonitenolide derivatives from the aerial parts of Centaurea gigantea inhibit the growth of colorectal cancer cells in vitro
    (Natural Products Inc, 2007) Shoeb, Mohammad; Celik, Sezgin; Nahar, Lutfun; MacManus, Stephen M.; Kong-Thu-lin, Paul; Jaspars, Marcel; Sarker, Satyajit D.
    The cytotoxic activity of two salonitenolide derivatives, 8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide (or arctiopicrin, 1) and 8-O-(4-hydroxy-3-methylbutanoyl)-salonitenolide,(2), isolated and identified from the methanol extract of the aerial parts of Centaurea gigantea, was assessed by the MTT cytotoxicity assay using the colon cancer cell line, CaCo-2. The IC50 values for 1 and 2 were found to be 8.5 and 26.4 mu M, respectively.