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    Effect of vitamin E on kidney histomorphology in rats exposed to bisphenol A
    (Cukurova Univ, Fac Medicine, 2020) Yıldız, Mustafa; Gules, Ozay; Boyacioglu, Murat; Kum, Sadiye
    Purpose: The aim of this study was to determine the effects of vitamin E on renal histomorphology in rats exposed to bisphenol A (BPA). Materials and Methods: The rats were randomly divided into four groups as sham, vitamin E, BPA and vitamin E+BPA. The applications of vitamin E and BPA were continued for three weeks. Crossman's triple staining method was applied to the sections obtained from kidney tissues for histomorphological examinations at the end of the experiment. Also, superoxide dismutase (SOD) activity and malondialdehyde (MDA) level were measured in kidney tissue. Results: The number of corpusculum renis, diameters of proximal tubule, distal tubule, ascending limb of Henle's loop and collecting duct as well as SOD activity significantly decreased in BPA group compared to sham group. Also, the number of corpusculum renis, diameters of ascending limb of Henle's loop and collecting duct as well as SOD activity significantly increased in vitamin E+BPA group compared to BPA group. On the other hand, MDA level significantly increased in BPA group compared to sham group and it significantly decreased in vitamin E+BPA group compared to BPA group. Conclusion: BPA may cause histomorphological and oxidative changes in the kidney. In addition, vitamin E may contribute to the preservation of renal tissue by reducing oxidative damage in BPA exposure.
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    Panax ginseng protects against copper sulfate-induced kidney toxicity in rats
    (Wolters Kluwer Medknow Publications, 2025) Gules, Ozay; Yildiz, Mustafa; Boyacioglu, Murat; Sevimli, Alper; Dayi, Belma
    Objective:To assess the protective effects of Panax ginseng (PG) against copper sulfate (CuSO4)-induced kidney toxicity in rats.Methods:The rats were randomly allocated into four groups: control, CuSO4, PG, and PG+CuSO4. The experiment continued for 14 days, during which CuSO4 was provided at a dosage of 100 mg/kg body weight per day and PG at 300 mg/kg body weight by oral gavage per day. Upon completion of the experiment, kidney sections were used for histological and histomorphometric analyses. The histochemical method was applied to ascertain the density of the glomerular mesangial matrix. The expressions of vascular endothelial growth factor (VEGF) and caspase-3 were examined using immunohistochemistry. The levels of malondialdehyde and glutathione, along with the activity of superoxide dismutase and catalase in the kidney, were measured.Results:PG treatment exhibited a marked protective effect against CuSO4-induced renal damage, as evidenced by improved histopathological lesions, significantly reduced glomerular mesangial matrix density, VEGF in distal tubules, caspase-3 expression, and malondialdehyde levels in renal tissue, as well as enhanced superoxide dismutase and catalase activities.Conclusions:PG treatment ameliorates CuSO4-induced kidney injury in rats. Further studies are warranted to verify its efficacy and elucidate the underlying mechanism of its nephroprotective action.
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    Protective effect of coenzyme Q10 against bisphenol-A-induced toxicity in the rat testes
    (Sage Publications Inc, 2019) Gules, Ozay; Kum, Sadiye; Yıldız, Mustafa; Boyacioglu, Murat; Ahmad, Ejaz; Naseer, Zahid; Eren, Ulker
    The present study was conducted to investigate the antioxidant, histomorphometric, histochemical, immunohistochemical, biochemical, and cytological effects of coenzyme Q10 (CoQ10) against bisphenol-A (BPA)-induced testicular toxicity in rats. A total of 40 adult male Wistar rats were divided into five equal groups. The control group remained untreated. The vehicle control group was administered corn oil (2 ml/kg/day), the BPA group was given BPA (100 mg/kg/day), the CoQ10 group was supplemented with CoQ10 (10 mg/kg/day), and the rats in the CoQ10-BPA group received CoQ10 (10 mg/kg/day) followed by BPA (100 mg/kg/day) 1 h later. The treatments were administered by oral gavage for 14 days. Results showed that the seminiferous tubule diameters (STDs) and seminiferous epithelium heights (SEHs) at stages VII-VIII and XII-XIV, number of undifferentiated embryonic cell transcription factor-1 (UTF-1) positive cells per tubule, UTF-1 positive tubules (%), plasma glutathione (GSH), and serum superoxide dismutase activities, testicular GSH activity and sperm viability (%) decreased whereas the number of terminal dUTP nick end labeling (TUNEL) positive cells per tubule, TUNEL positive tubules (%), testicular and serum malondialdehyde (MDA) levels, and the rate of mid-piece sperm abnormality increased in the BPA administered group. However, while the STDs at stages VII-VIII and XII-XIV, SEHs at stages VII-VIII, plasma GSH, and serum SOD activities increased, serum MDA level decreased in the CoQ10-BPA group. In conclusion, these results suggest a protective effect of CoQ10 against BPA-induced testicular toxicity in rats.
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    The effects of Vitamin E on periodic acid Schiff reaction, qfantity of argyrophilic Nfcleolar organizer regions and indfcible nitric oxide synthase expression in prostate of rats exposed to bisphenol A
    (Parlar Scientific Publications, 2019) Yıldız, Mustafa; Gules, Ozay; Sandikci, Mustafa; Kum, Sadiye
    The aim of the study is to determine the protective role of Vitamin E on the prostate of rats exposed to bisphenol A (BPA). A total of 40 adult male Wistar Albino rats were used. The rats were randomly divided into five groups as follows: control, sham, Vitamin E, BPA, and Vitamin E+BPA. The applications of Vitamin E (300 IU/kg/day) and BPA (10 mg/kg/day) were proceeded for three weeks. Periodic Acid Schiff (PAS) and Silver-Staining for Nucleolar Organizer Region (AgNOR) methods were applied to prostate sections for histochemical examinations. Also, inducible nitric oxide synthase (iNOS) expression was examined immunohistochemically. The number of AgNOR positive dots and intensity of iNOS expression in glandular epithelial cells of prostate increased in BPA group compared to control group. Also, iNOS expression decreased in Vitamin E+BPA group compared to BPA group. On the other hand, a significant difference wasn’t found between the groups in terms of PAS reaction. As a conclusion, our findings demonstrate that BPA might stimulate cell proliferation and oxidative changes in prostate. The usage of Vitamin E might contribute to reducing oxidative damage induced by BPA in prostate. © by PSP
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    THE EFFECTS OF VITAMIN E ON PERIODIC ACID SCHIFF REACTION, QUANTITY OF ARGYROPHILIC NUCLEOLAR ORGANIZER REGIONS AND INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION IN PROSTATE OF RATS EXPOSED TO BISPHENOL A
    (Parlar Scientific Publications (P S P), 2019) Yıldız, Mustafa; Gules, Ozay; Sandikci, Mustafa; Kum, Sadiye
    The aim of the study is to determine the protective role of vitamin E on the prostate of rats exposed to bisphenol A (BPA). A total of 40 adult male Wistar Albino rats were used. The rats were randomly divided into five groups as follows: control, sham, vitamin E, BPA, and vitamin E+BPA. The applications of vitamin E (300 IU/kg/day) and BPA (10 mg/kg/day) were proceeded for three weeks. Periodic Acid Schiff (PAS) and Silver-Staining for Nucleolar Organizer Region (AgNOR) methods were applied to prostate sections for histochemical examinations. Also, inducible nitric oxide synthase (iNOS) expression was examined immunohistochemically. The number of AgNOR positive dots and intensity of iNOS expression in glandular epithelial cells of prostate increased in BPA group compared to control group. Also, iNOS expression decreased in vitamin E+BPA group compared to BPA group. On the other hand, a significant difference wasn't found between the groups in terms of PAS reaction. As a conclusion, our findings demonstrate that BPA might stimulate cell proliferation and oxidative changes in prostate. The usage of vitamin E might contribute to reducing oxidative damage induced by BPA in prostate.