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Öğe A forgotten oat head aspiration in an adult patient(Termedia Publishing House Ltd, 2014) Gonlugur, Ugur; Karabacak, Ersin; Muratli, Asli; Mirici, Arzu[Anstract Not Available]Öğe A RESTRICTIVE PATHOLOGY IN A PAIIENT WITH HYPERCAPNIC RESPIRATORY FAILURE(Carbone Editore, 2012) Gonlugur, Ugur; Mirici, ArzuCarbon dioxide narcosis is an important finding in the emergency department. The differential diagnosis of hypercapnia allows to appropriate treatment. Some comorbid conditions can be confusing for the clinicians. In this paper, we present such an interesting case. Extrapleural abundant fat may mimic malignant mesothelioma, fibrothorax or encysted empyema.Öğe A restrictive pathology in a patient with hypercapnic respiratory failure(Acta Medica Mediterranea, 2012) Gonlugur, Ugur; Mirici, ArzuCarbon dioxide narcosis is an important finding in the emergency department. The differential diagnosis of hypercapnia allows to appropriate treatment. Some comorbid conditions can be confusing for the clinicians. In this paper, we present such an interesting case. Extrapleural abundant fat may mimic malignant mesothelioma, fibrothorax or encysted empyema.Öğe Acute Progressive Dyspnea in a Patient With Chronic Obstructive Pulmonary Disease(Marmara Univ, Inst Health Sciences, 2020) Gonlugur, Ugur; Gonlugur, TanseliThe cause of acute dyspnea in chronic obstructive pulmonary disease is challenging. A 69-year old man complained of dyspnea, and cough. He had a diagnosis of chronic obstructive pulmonary disease for 6 years. Oxygen therapy started for respiratory failure. At the 6th day of hospitalization, dyspnea progressively increased. Chest X-ray showed a right-sided radiolucency. The preliminary diagnosis was spontaneous pneumothorax but chest computerized tomography-scan demonstrated a space-occupying lesion in left main bronchus. The latter diagnosis was mucoid impaction but bronchoscopy revealed a malignant lesion. In conclusions, lung cancer can be a rare cause of acute dyspnea.Öğe An uncommon cause of multiple pulmonary nodules; hereditary hemorrhagic telangiectasia(Turkish Assoc Tuberculosis & Thorax, 2016) Kosar, Sule; Kizildag, Betul; Canan, Arzu; Karatag, Ozan; Gonlugur, Ugur; Sariyildirim, AbdullahHereditary hemorrhagic telangiectasia ( HHT), or Rendu-Osler-Weber syndrome ( ROWS) is a very rare hereditary disease. The diagnosis is based on the clinical findings such as recurrent epistaxis, telangiectases, visceral arteriovenous malformations (AVMs) and family history. AVMs are found in the liver, lung or brain and could mimick the masses of these organs. Radiologic evaluation plays a critical role during diagnostic and therapeutic management of ROWS. Hence, radiologists should be aware of the diagnosis of HHT in the patients with AVMs, history of epistaxis and family history. We report a patient with multiple pulmonary AVMs secondary to HHT who has referred to our interventional radiology department for computed tomography guided transthorasic lung biopsy procedure with suspicious of malignancy.Öğe Benign metastasizing leiomyoma(Springer, 2008) Sapmaz, Feride; Ergin, Makbule; Katrancioglu, Ozgur; Gonlugur, Tanseli; Gonlugur, Ugur; Elagoz, SahendeA 41-year-old woman presented with chest pain and a cough. There was a solitary pulmonary nodule in the upper-left lobe. The patient had no history of neoplasm except a hysterectomy for uterine leiomyoma five years before. Six months after the first presentation, the tumor showed a gradual increase in size; an explorative thoracotomy was performed. The histopathologic examination showed a tumor consisting of well-differentiated spindle-shaped cells with intervening collagen. She was readmitted 8 months after the operation because of right-sided spontaneous pneumothorax. Multiple pulmonary nodules appeared when the lung was re-expanded by chest tube drainage. In conclusion, uterine leiomyomas can metastasize to various organs, such as lungs, despite having a benign pathologic appearance.Öğe Cervical necrotizing fasciitis associated with descending necrotizing mediastinitis(Biomed Central Ltd, 2011) Gonlugur, Ugur; Guclu, Oguz; Karatag, Ozan; Mirici, Arzu; Derekoy, SefaWe report a case of potentially fatal cervical necrotizing fasciitis and descending necrotizing mediastinitis due to deep neck infection in a 66-year-old male patient with no history or evidence of immunocompromising disorders. On admission, he had painful neck movements and the skin over his neck was red, hot and tender. A computerized tomography (CT) scan of his neck and chest showed evidence of air collection in soft tissues. He was treated with broad-spectrum intravenous antibiotics and early massive cervical drainage. Prompt diagnosis by CT of the neck and chest enabled an early surgical treatment of cervical necrotizing fasciitis. Although acute mediastinitis is a fatal infection involving the connective tissues that fill the interpleural spaces and surround the median thoracic organs, an extensive cervicotomy combined with appropriate antibiotics can prevent the need for mediastinal drainage.Öğe COVID-19 or not?(Doc Design Informatics Co Ltd, 2022) Gonlugur, Ugur; Resorlu, Mustafa; Sener, Alper; Gonlugur, TanseliBilateral multilobar ground-glass opacities are characteristic features of COVID-19 pneumonia. However, the dif-ferential diagnosis of ground-glass opacities is challenging. The aim of this paper was to share our experiences with other colleagues. The first patient presented with anosmia and loss of taste. Legionella antigen in urine was positive. The second patient had bilateral ground-glass opacities, which predominantly involved the upper lung zones and lym-phopenia. Radiological findings were the same with the radiological control of 8 months ago, and she had a diagnosis of sarcoidosis. The third patient complained of dyspnoea. The inspection of national health system records showed a histological diagnosis of nonspecific interstitial/organizing pneumonia. The fourth patient had findings suggestive of congestive heart failure such as bilateral pleural effusion, peribronchial cuffing, and interlobular septa thickening. The co-existence of multiple ill-defined centrilobular ground-glass opacities suggested a concomitant disease but lesions disappeared with furosemid infusion within 5 days. The fifth patient presented with only right upper lobe consolida-tion. The opacities did not exceed the horizontal fissure. The intact fissure suggested a bacterial aetiology, but PCR tests of the nasopharyngeal samples were positive for COVID-19. This finding suggested that pulmonary infiltrate of COVID-19 was inflammatory rather than infective in nature. In conclusion, old imaging studies were more useful in the differential diagnosis.Öğe Eosinophilic bronchitis without asthma(Karger, 2008) Gonlugur, Ugur; Gonlugur, Tanseli EfeogluBackground: Eosinophilic bronchitis without asthma causes chronic coughs without the physiologic features of asthma. The aim of this study was to review the clinical features, pathogenesis, diagnosis, treatment and prognosis of this condition. Methods: The current literature was reviewed using Pubmed for all studies published in the English language using the search term 'eosinophilic bronchitis'. Results: Eosinophilic bronchitis presents as normal spirometry, without evidence of airway hyperresponsiveness, and normal peak expiratory flow variability. When compared with asthma, mast cell recruitment to the superficial airways and mast cell activation appear to be a feature of eosinophilic bronchitis. In contrast, mast cell infiltration in the smooth muscle is significantly higher in asthma patients than in either eosinophilic bronchitis patients or healthy control subjects. In this condition, the absence of high IL-13 expression can contribute to the normal airway reactivity. The cough usually responds well to inhaled corticosteroids but dose and duration of treatment remain unclear. The condition can be transient, episodic or persistent unless treated, and occasionally, patients may require long-term treatment with oral corticosteroids. Conclusions: The condition is an important cause of chronic coughs which are corticosteroid responsive. The study of eosinophilic bronchitis suggests that eosinophil-dependent mechanisms are generally not important in the pathogenesis of asthma. Copyright (C) 2008 S. Karger AG, Basel.Öğe Evaluation of the clinical characteristic of psychiatric patients who are among the risk groups in the COVID-19 pandemic(Bayrakol Medical Publisher, 2022) Mutlu, Pinar; Oyekcin, Demet Gulec; Mirici, Arzu; Gonlugur, UgurAim: The pandemic caused by COVID-19 has been a major concern for public health worldwide. Traditional medical practices need to be adapted quickly to meet the needs of vulnerable patients due to the COVID-19 outbreak. One of these patient groups is the mentally ill. Although COVID-19 itself affects mental health, this study aimed to investigate the clinical characteristics of COVID-19 patients who were previously diagnosed with mental illness. Material and Methods: Patients older than 18 years of age with COVID-19 pneumonia, PCR positive or negative, thoradc CT compatible with COVID-19 pneumonia, and who also had been diagnosed with psychiatric disease between 1 April - 1 October 2020 were included in the study Psychiatric diagnoses of the patients, drugs they used, places they lived, PCR results, CT results, comorbidities, the treatment of COVID-19, and the final status of the patients were evaluated. Results: Between the specified dates, the number of patients with COVID-19 with psychiatric disease was 37 (28.24%) out of 131. The average age of patients with COVID-19 was 56.63 +/- 11.25 years, and the average length of stay in the hospital was 5.57 +/- 1.52 days. There were 35 (94.6%) patients living in a nursing home. There were 26 patients (70.3%) with a previous history of psychiatric illness, and 23 of them (62.2%) had psychotic disorders. During the treatment period, 27 (73.0%) of the patients received multiple pharmacotherapies, and atypical antipsychotic drugs (51.4%) were mostly prescribed. Discussion: As a result, in our study, we determined that living in nursing homes, having a psychiatric disorder, and taking multiple pharmacotherapies due to this psychiatric disorder increase the possibility of getting COVID-19.Öğe Evaluation of the Hospitalized Coronavirus Disease 2019 Patients in First 3 Months of the Pandemic(Aves, 2022) Alkan, Sevil; Akca, Anil; Sener, Alper; Dogan, Ebru; Gonlugur, Ugur; Simsek, Tuncer; Ozer, SuleOBJECTIVE: Data about Turkish coronavirus disease 2019 patients are limited. We evaluated hospitalized coronavirus disease 2019 patients who were followed up in the first 3 months of the pandemic. MATERIAL AND METHODS: This retrospective, single-center, observational study included 415 confirmed hospitalized coronavirus disease 2019 patients. The patients were divided into groups, namely, mild, moderate, and critically ill patients. Symptoms at the time of admission, clinical, laboratory, and imaging findings were examined. RESULTS: In our study, 6.74% of coronavirus disease 2019 patients had severe disease, 59.5% were male, and the mortality rate was 11.3%. Diabetes mellitus and chronic obstructive pulmonary disease were more frequently seen in critically ill patient groups and hyper- tension in moderate patient groups. Anemia and aspartate aminotransferase levels were higher in non-survivors among mild coronavirus disease 2019 patients. In the moderate patients' group, aspartate aminotransferase, lactate dehydrogenase, international normalized ratio, ferritin, and D-dimer levels were higher and lymphocyte, hemoglobin levels were lower; in the critically ill patients' group, platelets were lower and uric acid levels were higher in non-survivor patients. CONCLUSION: In mild patients, anemia, lymphopenia, and increased aspartate aminotransferase levels; in moderate patients, leukopenia, anemia, and increased aspartate aminotransferase, lactate dehydrogenase, international normalized ratio, ferritin, and D-dimer levels; in the critically ill patient group, lower platelet and increased uric acid levels should he followed closely as they are mortality predictors.Öğe Intraosseous Lipoma of the Rib(Elsevier Science Inc, 2009) Katrancioglu, Ozgur; Sapmaz, Feride; Gonlugur, Tanseli E.; Elagoz, Sahande; Gonlugur, Ugur[Anstract Not Available]Öğe Loculated transudate(Cukurova Univ, Fac Medicine, 2020) Gonlugur, Ugur; Gonlugur, Tanseli; Ozer, Sule[Anstract Not Available]Öğe MEDICAL TREATMENT IN PULMONARY HYPERTENSION(Nobel Ilac, 2011) Mirici, Arzu; Gonlugur, UgurSignificant advances in the treatment of pulmonary arterial hypertension have occurred in the last decade. Over this same period, the classification of pulmonary hypertension has also been revised. The most important drugs in the therapy are calcium-channel antagonists, prostanoids, endothelin antagonists, and phosphodiesterase 5 inhibitors. The therapeutic option changes according to the New York Heart Association classification in such patients. The aim of this review is to describe the current state for the treatment of the patients with pulmonary arterial hypertension.Öğe Middle Lobe Syndrome Associated with Bronchial Anthracofibrosis(Vilnius University Press, 2020) Gonlugur, Ugur; Gonlugur, Tanseli; Ozer, SuleBronchial anthracofibrosis has been defined as airway narrowing associated with dark pigmentation on bronchoscopy without an appropriate history of pneumoconiosis or smoking. We present a case of a 67-year-old, non-smoking female patient who was referred to our clinic for two years of persistent cough. Spirometry was within normal limits. Radiological evaluation showed right middle lobe atelectasis and positron emission tomography-positive mediastinal lymph nodes. Bronchoscopy revealed black airway discoloration and distortions. In conclusion, we propose monthly radiological controls before an invasive procedure in such cases if a strong suspicion of malignancy/tuberculosis is not present. © 2020 Ugur Gonlugur, Tanseli Gonlugur, Sule Ozer. Published by Vilnius University Press.Öğe Middle lobe syndrome in left lower lobe(Inst Investigacion Clinica, 2019) Gonlugur, Ugur; Gonlugur, TanseliMiddle Lobe Syndrome is a term that refers to a persistent or recurrent collapse of a lung lobe, especially the right middle lobe. A 66-year-old woman presented with chronic cough with sputum and recurrent attacks of pneumonia. She was treated with antibiotics. Chest CT-scan showed a left lobe atelectasis and multiple foci of bronchiectasis. Bronchoscopy revealed a patent left lower lobe bronchus. In conclusions, middle lobe syndrome can rarely affect left lower lobe. It should be kept in mind in the differential diagnosis of recurrent pneumonia.Öğe Pancreatic involvement in small cell lung cancer(Walter De Gruyter Gmbh, 2014) Gonlugur, Ugur; Mirici, Arzu; Karaayvaz, MuammerBackground. Few data are available concerning incidence, clinical picture, and prognosis for pancreatic metastases of small cell lung carcinoma. In this paper we review the related literature available in English language. Conclusions. Although pancreatic metastases are generally asymptomatic, they can rarely produce clinical symptoms or functional abnormalities. The widespread use of multi-detector computerised tomography (CT) in contemporary medical practice has led to an increased detection of pancreatic metastases in oncology patients. Tissue diagnosis is imperative because radiological techniques alone are incapable of differentiating them from primary pancreatic tumours. Pancreatic metastases occur in the relative end stage of small cell lung cancer. The main complications of these lesions, although rare, are acute pancreatitis and obstructive jaundice. Early chemotherapy can provide a survival benefit even in patients with mild acute pancreatitis or extrahepatic biliary obstruction.Öğe Pleural fluid findings as prognostic factors for malignant pleural mesothelioma(Wiley, 2008) Gonlugur, Tanseli Efeoglu; Gonlugur, UgurThe aim of this study was to determine the prognostic value of pleural fluid glucose, lactate dehydrogenase (LDH), albumin, total protein, and total leukocyte levels in patients with malignant pleural mesothelioma. We retrospectively analyzed 71 consecutive patients (33 men and 38 women) who were referred to the department of chest diseases in a university hospital. Pleural fluid glucose levels, the ratio of pleural fluid to serum LDH > 1.0, and total leukocyte count were significant predictors for the survival in univariate analysis. However, none of these variables emerged as statistically significant from the multivariate Cox model. In conclusion, our results showed that there is an inverse correlation between the intensity of inflammation and survival.Öğe Prognostic Factors for 100 Patients With Malignant Pleural Mesothelioma(Heldref Publications, 2010) Gonlugur, Ugur; Gonlugur, Tanseli EfeogluThe aim of this study was to investigate the effects of various clinical, laboratory characteristics, and therapeutic modalities on the survival of patients with malignant pleural mesothelioma. One hundred consecutive patients with a pathologically proven diagnosis of malignant pleural mesothelioma treated between 1993 and 2005 were included in the study. Using a Cox proportional hazard model, comorbidity, weight loss, breathlessness, and performance status were identified as independent prognostic factors. Comorbidity had interestingly favorable effect on the survival. Treated patients with chemotherapy had significantly longer survival than those treated with best supportive care. However, it was necessary to complete at least 6 cycles for a survival benefit. In conclusions, comorbidity information should be recorded in the recent prognostic studies. The drugs used for the comorbidity may improve survival.Öğe Pulmonary barotrauma during hookah diving: a case report(Undersea & Hyperbaric Medical Soc Inc, 2020) Korpinar, Sefika; Gonlugur, Ugur; Kapicibasi, Oguz; Gonlugur, Tanseli; Toklu, Akin SavasWhen commercial sea harvesters have dive accidents, it is sometimes difficult to obtain an accurate dive history and make a definitive diagnosis. We report a sea harvest diver who dived to collect sea snails (Rapana venosa) by using a hookah dive system. He experienced mediastinal and subcutaneous emphysema due to interruption of breathing airflow. Thoracic computed tomography performed one year prior to the accident revealed paramediastinal subpleural blebs on both lung apices. Emphysema was resolved by administering normobaric oxygen.
