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Öğe Can the addition of a paracervical block to systemic or local analgesics improve the pain perceived by the patient during hysterosalpingography?(Taylor & Francis Inc, 2014) Hacivelioglu, S.; Gencer, M.; Gungor, A. Cakir; Kosar, S.; Koc, E.; Cosar, E.The aim of the present study was to investigate whether the addition of a paracervical block to local intrauterine anaesthesia or the use of an intramuscular non-steroidal anti-inflammatory drug was effective for pain control during and at 30 min after hysterosalpingography (HSG). A total of 120 patients undergoing hysterosalpingography were randomised into four groups. Patients received intramuscular dexketoprofen trometamol with or without a paracervical block or intracavitary lidocaine instillation with or without paracervical block. The primary outcome was the overall pain score from the four stages of the procedure. The lowest pain scores were observed in the patients receiving dexketoprofen trometamol with a paracervical block, whereas the highest pain scores were observed in patients with intracavitary lidocaine instillation without a paracervical block (p = 0.021). No beneficial effect was found when a paracervical block (PCB) was added to either systemic or local analgesics. The combination of intramuscular dexketoprofen and a paracervical block with plain lidocaine produced the best pain relief during the three specified steps and at up to 30 min after the HSG procedure.Öğe Does pregnancy-induced hypertension affect the electrophysiology of the heart?(Taylor & Francis Inc, 2016) Gazi, E.; Gencer, M.; Temiz, A.; Barutcu, A.; Altun, B.; Gungor, A. N. C.; Hacivelioglu, S.Pregnancy-induced hypertension (PIHT) increases both maternal and neonatal mortality and morbidity in pregnant women. We sought to investigate the electrocardiographic findings in pregnant women with PIHT. Seventeen pregnant women (29.4 +/- 5 years) with PIHT and 24 pregnant women (27.3 +/- 6.1 years) with normal blood pressure (control group) were included in the study. A 12-lead surface electrocardiogram was used to evaluate the electrocardiographic parameters. Pregnant women with PIHT had higher blood pressure (p = 0.001). The Tp-e interval was longer in PIHT pregnant women at 83.5 +/- 7.8 ms versus 75.8 +/- 8.4 ms in the control group (p = 0.007). The Tp-e/QTc ratio was higher in pregnant women with PIHT than that in healthy controls (0.19 +/- 0.02 vs. 0.18 +/- 0.02, respectively). This study demonstrated that Pd, QTd and the P wave durations were similar in the PIHT pregnant women and control group, but the Tp-e and Tp-e/QTc ratio were higher in pregnant women with PIHT than in normotensive pregnant women.Öğe HPV and HPV vaccination: knowledge and consciousness of young women(I R O G Canada, Inc, 2014) Coşar, E.; Gencer, M.; Hacıvelioğlu, S. O.; Güngör, A. C.; Uysal, AhmetAim: The aim of the study was to explore the knowledge and the awareness of the young Turkish women regarding cervical cancer and human papilloma virus (HPV) vaccines. The authors analyze a probable relationship between the overall knowledge level and a few socio-demographic parameters. Materials and Methods: The authors interviewed with students from Canakkale 18 March University and young women that did not continue with school in the same city from January to September 2011. All the students answered the questionnaire voluntarily and independently. Results: The participants had low level of knowledge about the risk factors for cervical cancer. Smoking is the major risk factor that was known by the participants (65%). Proportion of the participants that were aware of pap smear test and HPV were 65% and 17% respectively. A small proportion of young women had knowledge regarding protection from HPV. Educational stream, educational level, family income, and family size had significant association knowledge level (p < 0.05). Conclusion: There has not been any improvement in HPV and risk factor of cervical cancer awareness in young women. Health members of the National Cancer Control Programme and delegates of the vaccine corporations have major work in order to increase the level of knowledge so that general public can easily take preventative measures.Öğe İntraüterin inseminasyon uygulanan hastalarda r-FSH ve klomifen sitrat ile ovülasyon indüksiyon sonuçlarının karşılaştırılması: 130 siklusun analizi(2013) Hacıvelioğlu, S.; Gencer, M.; Güngör, A. N. Çakır; Uysal, A.; Coşar, E.Amaç: İntraüterin inseminasyon (İUİ) uygulanan hastalarda ideal ovülasyon indüksiyon (Oİ) protokolünün hangisi olduğu henüz net olarak bilinmemektedir. Bu retrospektif çalışmanın amacı, İUİ yapılan hastalarda Oİ için kullanılan rekombinan FSH (r-FSH) ve klomifen sitrat (KS)'ın gebelik oranları üzerindeki etkilerini ortaya koymaktır.Gereç ve Yöntem: Taze eş spermi ile İUİ uygulanan 130 siklus retrospektif olarak değerlendirildi. Çalışma iki tedavi grubundan oluştu; birinci gruba r-FSH + İUİ yapılan 35 tedavi siklusu ve ikinci gruba KS+İUİ yapılan 95 tedavi siklusu dahil edildi. Bu iki grup çeşitli klinik ve laboratuar parametreler yönünden karşılaştırıldı.Bulgular: Gebelik oranı r-FSH grubunda %17,1 ve KS grubunda %10,5 olarak saptandı ve aralarında istatistiksel fark bulunmadı (p=0,368). hCG günündeki endometrium (EM), KS grubunda daha ince izlendi (p <0,001). EM kalınlığı 7 mm altında olan hastaların oranı KS grubunda daha fazlaydı (p=0,012). Fakat 7 mm altındaki ve üstündeki EM değerlerinde her iki tedavi grubunda da gebelik oranları istatistiksel olarak benzerdi (p=0,773).Sonuç: KS ile yapılan indüksiyonlara hCG günü EM kalınlığı r-FSH grubuna göre daha ince izlenmekle birlikte, 7 mm altındaki bu ince EM'lerde gebelik oranının değişmediği görüldü. İUİ yapılan hastalarda ovülasyon indüksiyonu için kullanılan r-FSH ve KS'nin gebelik oranları benzer olduğundan, bu hastalarda daha ucuz ve enjeksiyon gerektirmeyen KS tedavisi r-FSH'a karşı etkin bir alternatif olabilir.Öğe Mean platelet volume and platelet distribution width can be related to bone mineralization(Springer London Ltd, 2014) Akbal, A.; Gokmen, F.; Gencer, M.; Inceer, B. S.; Komurcu, E.Platelets functions are related to bone resorption and formation. The present study aimed at studying the association between platelet function and bone mineralization. We showed that mean platelet volume (MPV) and platelet distribution width (PDW) levels in osteoporosis patients increased. The study also showed that PDW and age independently associated with bone mineralization. MPV and PDW are widely used for assessing platelet function. Recently, authors argued that platelet function has an important role in bone mineralization. However, only one study has investigated the relationship between MPV and osteoporosis. We aimed to study the levels of MPV and PDW in postmenopausal osteoporosis. We investigated 320 bone mineral density (BMD) measurements between the years 2012 and 2013 retrospectively in our clinic. Eighty patients whom chronic diseases are absent and all laboratory findings are complete enrolled in this study. Patients were divided in three groups as an osteoporosis, osteopenia, and normal BMD group. MPV and PDW levels were investigated in these groups. We performed correlation test and linear regression analysis to determine whether there is a relationship between platelet function markers and BMD measurements. Eighty patients were divided as an osteoporosis, osteopenia, and normal BMD group. MPV levels and PDW levels in the osteoporosis group were lower than the normal BMD group. PDW was positively correlated with femur total T (FTT) score and lumbar 1-4T (L1-4T) scores. Linear regression analysis showed that age and PDW were independently related to FTT and LTT scores. Platelet functions are related to the bone mineralization. PDW and MPV have a significant role in the development of postmenopausal osteoporosis.Öğe Stria gravidarum is genetic but not related with collagen gene polymorphism(Gene Therapy and Molecular Biology, 2013) Cakir Gungor, Ayse Nur; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.Background: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. Methods: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. Results: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, %95CI 0.36-4.86, p=0.66). Conclusion: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.Öğe Stria Gravidarum Is Genetic But Not Related With Collagen Gene Polymorphism(Gene Therapy Press, 2013) Gungor, Cakir A. N.; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.BACKGROUND: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. METHODS: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. RESULTS: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, % 95CI 0.36-4.86, p= 0.66). CONCLUSION: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.Öğe The effect of maternal polycystic ovary morphology on first-trimester maternal serum biochemical markers of aneuploidy and fetal nuchal translucency thickness(Imr Press, 2015) Hacivelioglu, S.; Uysal, A.; Gungor, A. N. Cakir; Gencer, M.; Cakir, D. U.; Cosar, E.Objective: To evaluate the effect of maternal polycystic ovary (PCO) morphology on maternal serum free beta-human chorionic gonadotropin (beta-hCG), pregnancy associated plasma protein A (PAPP-A), and nuchal translucency (NT) thickness in the first-trimester. Material and Methods: A total of 92 pregnant women in the first-trimester were included in the study. Of them, 57 had PCO morphology, and 35 women constituted the control group, with apparently normal ovaries. Maternal serum free beta-hCG, PAPP-A, and NT thickness were measured and compared in all patients. Results: The multiples of median (MoM) levels of serum free beta-hCG were significantly higher in the PCO morphology group compared to the normal ovary group (p = 0.024). However, the MoM levels of PAPP-A were similar in both groups (p = 0.947). No difference was found between the groups in terms of fasting glucose levels and NT measurements (p = 0.976 and 0.565, respectively). Conclusion: In pregnancies with maternal PCO morphology, the presence of higher maternal serum free beta-hCG levels may require correction in the calculation of risks related to first-trimester screening for chromosomal abnormalities. Larger studies are needed to confirm our preliminary data.
