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Öğe Genotoxicity evaluation of a new phthalazine substituted ?-lactam derivative in human lymphocytes(Acad Brasileira De Ciencias, 2022) Aygun, Betul; Berber, Ahmet A.; Doganci, Merve A.; Berber, Nurcan; Sen, Selen; Yildiz, Esra; Aksoy, HuseyinThe aim of present study, to evaluate the genotoxic potential of 1-(4-(3,3-dimethyl-1,6-dioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b] phthalazine-13yl) phenyl)-2-phenylazetidine-3-yl-acetate which was synthesised assuming that it may be a pharmaceutical raw material and found to inhibit human carbonic anhydrase I, II isozymes. To determine the genotoxic potential of this phthalazine substituted beta-lactam compound, chromosomal aberration (CA) and micronucleus (MN) tests were implemented in human peripheral blood lymphocytes. In these tests, lymphocyte cultures were treated with four concentrations (30, 15, 7.5, 3.75 mu g/mL) of test compound and simultaneously with negative control (sterile distilled water), solvent control (DMSO) positive control (MMC). According to our results, CA frequencies were significantly increased in two high applied concentrations (30, 15 mu g/mL) compared with negative and solvent control. MN frequencies were significantly increased in three applied concentrations (30, 15, 7.5 mu g/mL) except lowest concentration (3.75 mu g/mL) compared with solvent control. Mitotic indices were also affected by treatment with test compound. The obtained results provide evidence to demonstrate that new phthalazine substituted beta-lactam derivative can exert genotoxic and cytotoxic effects in peripheral human lymphocytes especially at high concentrations.Öğe INDUSTRIAL TRIAL to PRODUCE of ENVIRONMENTALLY FRIENDLY INSULATION MATERIAL with INORGANIC RESIN(Parlar Scientific Publications, 2020) Berber, NurcanRockwool is made from igneous volcanic rocks and blast furnace slag. The manufacturing process starts the melting of dolomite basalt and coal as fiber in 1380-1500 ° C and then it is transformed 97% natural fiber. Generally, the rockwool fibers are adhered to each other, a mixture called "Binder" is used. This binder can be prepared from chemicals such as phenol-formaldehyde resin, silane, silicone and process oil. It can also be prepared using different chemicals such as anhydride, amine, reducing sugars. As an alternative, in this study we tried to produce environmentally friendly rockwool insulation material with high thermal resistance, odorless and high strength with inorganic resin. In the products, all values except water absorption and dimensional stability were obtained within limits. © by PSPÖğe INDUSTRIAL TRIAL TO PRODUCE OF ENVIRONMENTALLY FRIENDLY INSULATION MATERIAL WITH INORGANIC RESIN(Parlar Scientific Publications (P S P), 2020) Berber, NurcanRockwool is made from igneous volcanic rocks and blast furnace slag. The manufacturing process starts the melting of dolomite basalt and coal as fiber in 1380-1500 degrees C and then it is transformed 97% natural fiber. Generally, the rockwool fibers are adhered to each other, a mixture called Binder is used. This binder can be prepared from chemicals such as phenol -formaldehyde resin, silane, silicone and process oil. It can also be prepared using different chemicals such as anhydride, amine, reducing sugars. As an alternative, in this study we tried to produce environmentally friendly rockwool insulation material with high thermal resistance, odorless and high strength with inorganic resin. In the products, all values except water absorption and dimensional stability were obtained within limits.Öğe Kinesin-5 inhibitörü olan Monastrol bileşiğinin sentezi ve yük transferi kompleks etkileşmelerinin incelenmesi(2016) Berber, Nurcan; Arslan, MustafaKinesin-5 inhibitörü olarak kullanılan Monastrol, çözücüsüz ortamda alümina sülfonik asit (ASA) katalizörü varlığında 3-hidroksibenzaldehit, tiyoüre ve etilasetoasetat kullanılarak sentezlenmiştir. Elektron verici (Donör, D) olarak monastrol, elektron alıcı (Akseptör, A) olarak tetrasiyanoquinometan (TCNQ) kullanılmış ve bunlar ile 2,3dikloro-5,6-disiyano-p-benzokinon (DDQ) bileşikleri arasındaki yük transfer kompleksleri asetonitril içinde 21 °C'de spektrofotometrik olarak incelenmiştir. Komplekslerin stokiyometrisi, Job yöntemi kullanılarak incelenmiş, elektron verici ve alıcılar arasında TCNQ ile 742 nm ve DDQ ile 546 nm dalga boyunda maksimum absorbsiyon bandında 1:1 oranında olduğu bulunmuştur. Komplekslerin denge sabiti Benesi-Hildebrand ve termodinamik parametreleri Van't Hoff denklemi ile belirlenmiştir.Öğe Multi-component preparation of indeno[2',1':5,6]pyrido[2,3-d]pyrimidine and reduction reaction(Parlar Scientific Publications, 2020) Berber, NurcanPyrimidine and their derivatives play an important role in the field of pharmacological activity. Also, pyrimidine compounds containing pyrido pyrimidine structure show significant biological and pharmaceutical activities. In this study, indeno [2',1':5,6]pyrido[2,3-d]pyrimidine derivative was synthesized by the one-pot condensation. This one-pot, three-component condensation took place under mild conditions; 1,3-Indandione (indanedione) (l), 6-amino uracil (2), 4-nitro benzaldehyde (3) in DMF/Et3N at 60 °C. The reaction was completed after 24 h. Also, eight different methods were tried for the reduction of aryl nitro group. For the selective reduction of aryl nitro group in a good yields was used under elemental sulfur (S8), sodium sulphide (Na2S) in THF/water at 100 °C conditions. All coumpounds were characterized by spectroscopic techniques. © by PSPÖğe MULTI-COMPONENT PREPARATION OF INDENO[2?,1?:5,6]PYRIDO[2,3-d]PYRIMIDINE AND REDUCTION REACTION(Parlar Scientific Publications (P S P), 2020) Berber, NurcanPyrimidine and their derivatives play an important role in the field of pharmacological activity. Also, pyrimidine compounds containing pyrido pyrimidine structure show significant biological and pharmaceutical activities. In this study, indeno [2',1':5,6]pyrido [2,3-d]pyrimidine derivative was synthesized by the one-pot condensation. This one-pot, three-component condensation took place under mild conditions; 1,3-Indandione (indanedione) (1), 6-amino uracil (2), 4-nitro benzaldehyde (3) in DMF/Et3N at 60 degrees C. The reaction was completed after 24 h. Also, eight different methods were tried for the reduction of aryl nitro group. For the selective reduction of aryl nitro group in a good yields was used under elemental sulfur (S8), sodium sulphide (Na2S) in THF/water at 100 degrees C conditions. All coumpounds were characterized by spectroscopic techniques.Öğe Preparation and Characterization of Some Schiff Base Compounds(Adiyaman University, 2020) Berber, Nurcan; Arslan, MustafaSchiff bases (imines) have been frequently used in various fields such as medicine, pharmaceutical purposes due to their various biological properties. In this study, nine new imine compounds (3a-h) were synthesized from 1-naphthyl amine with aromatic aldehydes in MeOH and their chemical structures were defined by 1H/13C NMR, IR and elemental analysis studies. We observed a singlet one hydrogen of the imines (–CH=N–) at 8.56–8.86 ppm in the 1H NMR spectra and also carbon of the Schiff bases (–CH=N–) at 158.2-163.4 ppm in the 13C NMR spectra. Also the IR spectra displayed the (–C=N–) characteristic absorption band at around 1600 cm-1. The obtained characteristic peaks at the expected locations proved the structural accuracy of the synthesized new derivative Schiff bases. © 2020, Adiyaman University. All rights reserved.Öğe Prunus avium’dan ekstrakte edilen total antosiyaninlerin genoprotektif etkisi(2017) Berber, Ahmet Ali; Berber, Nurcan; Sönmez, Fatih; Demir, Taki; Aygün, Betül; Doğancı, Merve Ayşe; Aksoy, HüseyinKiraz (Prunus avium) antosiyanin gibi immün sistem için faydalı olan flavonoidler açısından oldukçazengin bir bitkidir. Bu çalışmada amaç Prunus avium’dan ekstrakte edilen total antosiyaninlerin (TAP) invitro antigenotoksik ve antisitotoksik etkilerini insan lenfositlerinde kromozomal anormallik (CA), tekhücre jel elektroforezi (Comet) ve Mikronükleus testleri (MN) ile değerlendirmektir. Çalışmamızda, insanlenfositlerinde mitomisin-C ve H2O2 ile indüklenen DNA hasarına karşı TAP’ın 50, 100, 200 and 400µg/mL’lik konsantrasyonlarının koruyucu etkisi gözlemlenmiştir. Ayrıca, pozitif, negatif ve çözücükontrol grupları da dahil edilmiştir. Pozitif kontrole göre TAP; 24 saatlik uygulamanın 200 ve 400µg/mL’lik, 48 saatlik uygulamanın ise tüm konsantrasyonlarında anormal hücre yüzdesini ve CA/hücrefrekansını istatistiksel olarak anlamlı bir şekilde azaltmıştır. Benzer şekilde TAP, mitotik indeksiistatistiksel olarak anlamlı bir şekilde 24 saatlik uygulamanın sadece 200 µg/mL’lik konsantrasyonundaartırırken, 48 saatlik uygulamanın ise tüm dozlarında (200 µg/mL’lik konsantrasyon hariç) artırmıştır. Busonuçlara paralel olarak TAP, MN frekansını da pozitif kontrole göre tüm konsantrasyonlarda istatistikselolarak anlamlı bir şekilde azaltmıştır. Comet testinde yapılan TAP uygulamasıyla tüm dozlarda kuyrukuzunluğu, kuyruk momenti ve kuyruk yoğunluğunda da anlamlı bir azalma olduğu gözlemlenmiştir. Eldeedilen bu sonuçlara göre, TAP’ın mitomisin-C ve H2O2 gibi genotoksik ajanlara karşı potansiyelantisitotoksik ve antigenotoksik koruyucu bir etkiye sahip olduğu gösterilmiştir.Öğe Synthesis and Characterization of Thiazole Compounds in the Presence of Various Reagents, Catalysts and Solvents(2022) Berber, NurcanThe reaction medium plays a key role in organic synthesis and pharmaceutical research. There are many opinions on choosing the best condition, including cost and environmental implications, but the main requirement is that they have the necessary interaction with solvents to cause dissolution, precipitation, stabilization, or instability. For this purpose, in this article synthesis of the thiazole ring was made under various reaction conditions. So new compounds 2-(isoquinolin-5-ylimino)-3-phenylthiazolidin-4-one (1), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (2), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (3) were synthesized from the reaction between thiourea derivative and monochloroacetic acid, diethyloxalate and chloro acetonitrile. For this synthesizes were created in various reaction conditions, using different bases (sodium acetate/sodyum etoksit/ triethylamine or pyridine) and solvents (1,4-dioxane, toluene, acetic acid, ethanol, tetrahydrofuran, dimethyl formamide). At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra as well as elemental analysis technique.Öğe Synthesis of Certain New Morpholine Derivatives Bearing a Thiazole Moiety(2019) Berber, NurcanMorpholine is a synthetic simple heterocyclic organic compound having characteristic functional groups ofamine and ether. Feasible physicochemical properties (polarity and solubility), low cost and wideavailability make it a suitable candidate for the synthesis of many potent drugs. In our work, we synthesizeda new series of thiazole substituted morpholine derivatives in two steps. In the first step, thiourea wassynthesized in THF at 70-75OC for 24 h and then in the second step the formation of thiazole ring wasensured in EtOH-DMF (5:5 v/v) at 60°C for 24 hours.Öğe Synthesis of new series of thiazol-(2(3H)-ylideneamino)benzenesulfonamide derivatives as carbonic anhydrase inhibitors(Wiley, 2020) Berber, Nurcan; Arslan, Mustafa; Vural, Firat; Ergun, Adem; Gencer, Nahit; Arslan, OktayHuman carbonic anhydrase I and II isoenzymes (hCA I and II) are important metabolic enzymes. In this study, a new series of thiazol-(2(3H)-ylideneamino)benzenesulfonamide derivatives were synthesized and also some inhibition parameters including IC50(hydratese) and inhibition constant values (K-i, esterase) were determined. All studied compounds exhibited potent inhibition against these enzymes. They inhibited carbonic anhydrases (CAs) with the IC(50)values of 113 to 395.8 nM (K-i = 77.38-319.59 nM) for hCA I and 91.9 to 516 nM (K-i = 62.79-425.89 nM) for hCA II. Among the compounds,5cwas found to be the most active one (K-i: 77.38 nM) for hCA I and5gwas found for hCA II with the value of 62.79 nM.Öğe Synthesis, characterization, carbonic anhydrase inhibitor activity, and docking studies of phenylthiazol-2 (3h)-ylidene-isoquinoline-5-amine Derivatives(Elsevier, 2023) Berber, Nurcan; Sahutoglu, Arif Sercan; Gokce, Basak; Cikrikci, Kuebra; Gencer, NahitPhenylthiazol-2(3h)-ylidene-isoquinoline-5-amine derivatives(5a-r) were easily prepared from 5-aminoisoquinoline, thioisocyanate, and phenacyl bromide derivatives in the presence of triethylamine in tetrahydrofuran (THF), and dimethyl formamide (DMF) in two steps. In the first step, thiourea was synthesized in THF reflux, 24 h and then in the second step, the formation of thiazole ring was ensured in EtOH-DMF (5:5 v/v), reflux, 24 h. The newly synthesized compounds were characterized using 1H NMR, 13C NMR, IR, and elemental analysis. The inhibitory effects of 18 newly synthesized compounds (5a-r) on hydratase and esterase activities of carbonic anhydrase isoenzymes (hCA I, II, IX, and X) were studied in vitro.
