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    A new angiographic finding: primary peripheral slow flow
    (Galenos Publishing House, 2021) Akşit, Ercan; Gazi, Emine; Kırılmaz, Bahadır; Aydın, Fatih
    In some peripheral angiographies, similar to the coronary slow flow phenomenon (CSFP), we observed a peripheral slow flow (Supplementary Video 1). Although slow flow phenomenon after infrapopliteal balloon angioplasty is mentioned in 2 retrospective studies1, 2, primary peripheral slow flow has been previously reported in only 1 case report.3 Interestingly, it appears that similar to CSFP sometimes occurring in a single coronary artery, there is slow flow only in the left lower extremity artery in the video example (Supplementary Video 1). There is also no severe stenosis that would explain this phenomenon. Moreover, considering that peripheral angiography was performed with the right femoral artery puncture and that the catheter was within the right femoral artery, it could have been expected for the flow to be slower in the right lower extremity artery with the effect of spasm.
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    A phenomenon to keep in mind in the imaging of peripheral arteries: Peripheral slow flow
    (Elsevier Ireland Ltd, 2021) Akşit, Ercan; Tok, Özge Özden
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    A Rare Arrhythmia Accelerated Junctional Rhythm in Pregnant Without Structural Heart Disease
    (Çanakkale Onsekiz Mart Üniversitesi, 2019-03-18) Akşit, Ercan; Gazi, Emine; Kırılmaz, Bahadır; Turgay Yıldırım, Özge; Aydın, Fatih
    Changes in the pregnancy, especially with an increase in sympathetic activation, may provide a basis for the development of dysrhythmias. A 27- year old woman within the 26 weeks of her pregnancy with no known cardiac disease admitted to our clinic with palpitation symptoms. Accelerated junctional rhythm with ventricular rate 90/bpm was observed in her electrocardiogram. No structural heart disease was detected during examination. Accelerated junctional rhythm was persisted at first and third month controls after initial examination. After delivery the rhythm was spontaneously converted to sinus rhythm.
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    A Rare Arrhythmia Accelerated Junctional Rhythm in Pregnant Without Structural Heart Disease
    (Çanakkale Onsekiz Mart Üniversitesi, 2019) Akşit, Ercan; Gazi, Emine; Kırılmaz, Bahadır; Yıldırım, Özge Turgay; Aydın, Fatih
    Gebelikte özellikle sempatik aktivasyonun artışı ile meydana gelen değişiklikler disritmilerin gelişimine zemin hazırlayabilir. Çarpıntı şikayeti ile kardiyoloji polikliniğine başvuran 27 yaşında 26 haftalık sağlıklı gebede elektrokardiyografide ventriküler hızı 90/dk olan akselere junctional ritim (AJR) görüldü. Yapısal kalp hastalığı saptanmayan gebede bir ay ve üç ay ara ile alınan EKG’lerinde AJR’nin devam ettiği, gebelikten sonra kontrolünde elektrokardiyografide AJR’nin kaybolduğu ve normal sinüs ritmine spontan olarak döndüğü görüldü.
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    Acil Servise Başvuran Hipertansiyon Hastalarının Klinik Özellikleri ve Acil Servise Başvuru Sıklığını Etkileyen Faktörlerin İncelenmesi
    (2020) Akman, Canan; Akşit, Ercan
    Giriş ve Amaç: Acil servis doktorları yüksek kan basıncı nedeniyle acil servise başvuran hastalar ile sık olarakkarşılaşmaktadır. Bu çalışmanın amacı, acil servise başvuran hipertansiyon hastalarının klinik özelliklerini ve acilservise başvuru sıklığını etkileyen faktörleri incelemektir.Gereç ve Yöntemler: Bu çalışmaya hastanemiz acil servisine başvuran daha önce hipertansiyon tanısı olan 100gönüllü hasta alınmıştır. Araştırmanın veri toplama aşamasında yüz yüze görüşülerek anket uygulanmıştır.Bulgular: Hastaların %52’sinde 10 yıldan fazladır hipertansiyon mevcuttu. Hastaların %81’ine yaşam tarzı değişikliğihakkında bilgilendirme yapılmıştır. Hastaların sadece %32’sine acil durumda kullanması için ilaç reçete edilmiştir.Takipte olduğu doktor tarafından, hipertansiyonun uç organlarına zarar verebileceği hastaların yalnız %40’ınaanlatılmıştır. Son bir yıl içinde hipertansiyon nedeni ile iki veya daha fazla sayıda acil servise başvuran hasta oranı%57’dir.Sonuç: Bu çalışma hipertansiyon tanısı ile bir yıl içinde iki veya üstü sayı ile acil servise başvurunun olduğunugöstermektedir. Hipertansiyon hastalarına hastalıkları hakkında ayrıntılı bilgilendirme yapmak hastaların acil servisebaşvuru sıklıklarını azaltabilir.
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    Acute Inferior Myocardial Infarction Caused by Lightning Strike
    (Cambridge Univ Press, 2018) Aydın, Fatih; Yıldırım, Özge Turgay; Dağtekin, Evrin; Hüseyinoğlu Aydın, Ayşe; Akşit, Ercan
    Lightning strike is an infrequent natural phenomenon with serious medical complications, like multiple organ damage, and it is associated with increased risk of mortality. Cardiovascular complications are among the most hazardous complications of lightning strike. Lightning strike can cause various serious consequences ranging from electrocardiographic changes to death. We reported a 21-year-old patient with no cardiovascular risk factors struck by lightning and presented by inferior ST elevated myocardial infarction (MI). The patient was followed up in the intensive care unit and MI complication did not develop during follow-up. The patient was lost due to multi-organ failure after 20 hours.
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    Ankilozan spondilit hastalarının diürnal kan basıncı değişkenliğinin normal popülasyonla karşılaştırılması
    (2019) Yıldırım, Özge Turgay; Gönüllü, Emel; Aydın, Mehmet Fatih; Dağtekin, Evrin; Aydın, Ayşe Hüseyinoğlu; Akşit, Ercan
    Amaç: Ankilozan spondilit (AS) hastalarında kardiyak tutulum %10-30 oranında görülür. Kronik inflamasyon, ankilozan spondilitte olduğugibi kardiyovasküler hastalıklar, hipertansiyon ve diürnal kan basıncı değişkenliğinin patofizyolojinde rol almaktadır. Azalmış kan basıncıdeğişkenliği kardiyovasküler olaylar için yüksek risk göstergesidir. Bu çalışma ile amacımız AS hastalarında diürnal kan basıncı değişikliğininnormal popülasyonla karşılaştırılmasıdır.Gereç ve Yöntem: Bu çalışma için 25 AS hastası ve 32 kontrol alınmıştır. Hipertansif hastalar, hipertansif tedavi almakta olan veya ambulatuarkan basıncı monitorizasyonu (ABPM) sonuçlarına göre gündüz kan basıncı ortalaması SKB/DKB>135/85 mmHg ve/veya gece kan basıncıortalaması SKB/DKB>120/70 mmHg olması şeklinde tanımlanmıştır. Dipper paterni gece kan basıncı ortalamasının gündüze oranla %10 vedaha fazla düşmesi olarak tanımlandı.Bulgular: Araştırmanın yaş ortalaması 42.5±12.1 yıldır ve % 63.2'si erkektir. Kontrol grubu ve AS grupları arasında temel demografik özellikler açısından anlamlı fark yoktur. ABPM sonuçlarına göre; AS grubunun %36’sı (n=9) ve kontrol grubunun %46.9’u (n=15) hipertansif olarakbelirlenmiştir ve gruplar arasında istatistiksel fark saptanmamıştır (p=0.290). AS hastaları ve kontrol grubu arasında ortalama, gündüz vegece; sistolik ve diyastolik kan basıncı sonuçları açısından anlamlı fark saptanmamıştır (p>0.05). AS hastalarının %76.0’ında (n=19) ve kontrol grubunun %71.8’inde (n=23) non-dipper patern saptanmıştır. Bu oranlar arasındaki fark istatistiksel açıdan anlamlı değildir (p=0.949).Gece gündüz arası sistolik kan basıncı değişkenlikleri açısından gruplar arasında fark saptanmamıştır (p=0.772).Sonuç: Çalışmamızın sonuçlarına göre non-dipper paterni ve diürnal kan basıncı değişimi AS hastalarında ve kontrol grubunda benzerdir.Hipertansif ve normotansif hastalar alt grup analizinde değerlendirildiğinde de gruplar arasında non-dipper hastaları ve diürnal kan basıncıdeğişkenliği açısından fark saptanmamıştır.
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    Assessment of Awareness Levels About Anticoagulants in Patients With Atrial Fibrillation Presenting to Emergency Department
    (Springer, 2021) Akman, Canan; Kırılmaz, Bahadır; Balcı, Serdal; Akşit, Ercan; Yurtseven, Ersan; Duygu, Ali
    Atrial fibrillation (AF) is a rhythm disorder observed mostly amongst adults. AF has been regarded as one of the most important medical problems because it leads to thromboembolism and paralysis risks. Although warfarin has been used in the past to cope with this health problem, new oral anticoagulant medicines have replaced it in the last few years. The new oral anticoagulants, namely, dabigatran etexilate, rivaroxaban, and apixaban, are currently being used in daily clinical practice and treatment guidelines. Since AF patients are supposed to receive long-term oral anticoagulant therapy, it is extremely important to provide them with accurate information and appropriate training regarding the treatment to decrease oncoming complications. This is a prospective study involving 168 patients who were admitted to the emergency department with AF and who were using oral anticoagulants. Findings indicate a lack of awareness in the patients regarding the effects and side effects of the drugs they take despite having been informed by the prescribing physician. We believe that informed action by patients with regard to the oral anticoagulants and their side effects will have an impact on the reduction in hospitalization observed. It will also make a substantial contribution to the quality of life of AF patients and to their use of medical services.
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    Assessment of secondary prevention awareness among patients with coronary artery disease: A survey including patients from 3 centers
    (Turkish Society of Cardiology, 2021) Aydın, Fatih; Akşit, Ercan; Yıldırım, Özgü Turgay; Aydın, Ayşe Hüseyinoğlu; Samsa, Murat
    Objective: In this study, we aimed to investigate the awareness of patients with coronary artery disease (CAD) about secondary prevention and the channels through which they obtained information on this issue. Methods: A standard questionnaire including 45 questions was given to the patients (n=912) who were admitted to the cardiology outpatient clinics to investigate their secondary prevention awareness and lifestyle. Results: Of the participants, 508 (55.7%) stated that they knew the condition of their vessels after coronary angiography; 493 (54.1%) stated that they did not exercise; 299 stated that they did not follow any specific diet. Men were more frequently aware of all risk factors except diet, blood glucose, and blood pressure compared to women (p<0.001). Women were more frequently aware that blood glucose and blood pressure are risk factors for CAD compared to men (p<0.001). The high-income patient group was more aware of all the risk factors, except blood glucose compared to the low/medium income patient group (p<0.001). The frequency of awareness, except for blood glucose and antiplatelet drugs, increased as the education level increased (p<0.001). However, the frequency of awareness of blood glucose and antiplatelet drug use was higher in the literate/ elementary school/secondary school group (p<0.001). In addition, it was concluded that patients' sexual life and psychological problems after being diagnosed with the disease were rarely questioned by cardiology specialists. Conclusion: Awareness of patients with CAD about secondary prevention was found to be very low.
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    Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?
    (Fatih BAŞAK, 2019) Yıldırım, Özge Turgay; Akşit, Ercan; Aydın, Fatih; Aydın, Ayse Hüseyinoglu; Dağtekin, Evrin
    Aim: Hypertension is a major risk factor for cardiovascular diseases and non-dipper status is associated with increased risk for cardiovascular events. Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are related to inflammation and cardiovascular risk. The purpose of the study is to investigate the relationship between NLR and PLR with non-dipper status of hypertensive and normotensive patients.  Methods:  A total of 482 patients were enrolled for the study. The study was planned as retrospective cohort study. Four groups were formed according to 24-h ambulatory blood pressure monitoring results. Group 1 was defined as hypertensive, non-dipper patients; group 2 as hypertensive, dipper patients; group 3 as normotensive, non-dipper patients and group 4 as normotensive, dipper patients.Results: Mean age of the study population was 50.1±15.5 years, 38.1% were male. According to the statistical analysis of Group 1 (n=165), Group 2 (n=88), Group 3 (n=123) and Group 4 (n=91) NLR was statistically different among groups (p<0.001). Group 1 had significantly higher values compared to Group 2 (p=0.001), Group 3 (p=0.002) and Group 4 (p=0.023). In hypertensive patient group, PLR values of Group 1 was significantly higher than Group 2 (p=0.002). Pearson correlation analysis showed that NLR and PLR were correlated with BP variability (r=-0.188, p<0.001 for NLR and r=-0.182 and p<0.001 for PLR). Regression analysis showed NLR (p=0.040), PLR (p=0.021), age (p=0.006) and hypertension (p<0.001) were independent predictors of BP variability.Conclusion: Our findings suggest that NLR and PLR can be used as inexpensive and easily accessible markers to detect non-dipper status in hypertensive patients
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    Cardio-intestinal inflammatory syndromes: What do we know for understanding this new entity?
    (Elsevier Ireland Ltd, 2023) Akşit, Ercan; Altay, Servet
    As physicians and researchers specialising in a particular field, we sometimes evaluate diseases only within the limits of our own area of expertise and forget to look at the big picture. In this context, we read with interest the article by Peretto et al. describing this new entity cardio-intestinal inflammatory syndrome, which may be related to increased cytokine levels especially tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1 and disruption of the gut microbiota.
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    CARDIOVASCULAR SYSTEM FEATURES OF YOUNG ADULTS BORN BY CESAREAN SECTION
    (2020) Akşit, Ercan; Gazi, Emine; Kırılmaz, Bahadır; Bozkurt, Hasan; Edinciklioğlu, Melike; Yıldırım, Özge Turgay
    Aim: Currently, the prevalence of caesarean section (CS) has been increasing at an alarming rate across the world. In parallel with theincreasing rate of CS, it is reported that there is an increasing prevalence of obesity, autoimmune and allergic diseases. The purpose ofthe present study is to analyse whether the cardiovascular system characteristics of young adults born by CS are different from those ofyoung adults born by vaginal delivery (VD).Materials and Methods: A total of 112 participants were included in the study (40 CS group vs 82 VD ie control group). Transthoracicechocardiography and carotid Doppler ultrasonography were performed to the participants. In addition, participants were evaluated witha 24-hour ECG recording.Results: Tricuspid E wave, tricuspid A wave and tricuspid E/A ratio were lower in the CS group compared with the control group(57.6±8.6 vs. 72.4±10.3, p<0.001; 46.7±8.8 vs. 50.6±8.9, p=0.04; 1.2±0.14 vs 1.45±0.88, p<0.001). Epicardial fat tissue thickness werehigher in the CS group compared with the control group (4.8±1.3 vs. 3.1±0.8, p<0.001).Conclusion: The results of this study show that cardiovascular system features of the young adults born by CS are different from thoseborn by VD. Further follow-up studies are needed to understand whether these findings will subsequently result in cardiovasculardiseases.
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    COMPARISON OF PLASMA ATEROGENIC INDEX BETWEEN DIABETES MELLITUS TYPES
    (Rating Academy, 2018) Akşit, Ercan; Yıldırım, Özge Turgay; Aydın, Ayşe Hüseyinoğlu; Aydın, Fatih
    Objective: Diabetes mellitus (DM) is a chronic metabolic disease that affects several systems and organs. Diabetic dyslipemia is considered to be one of the major macrovascular complications of DM. Plasma atherogenic index (PAI) is considered as an independent determining factor for cardiovascular disease (CVD). The aim of this study was to compare the PAI values ​​between Type-1 DM and type-2 DM patient groups
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    Comparison of plasma levels of Pre?1-HDL with EAT thickness in patients with chronic kidney disease
    (Turkish Society of Nephrology, 2021) Bakırdöğen, Serkan; Çakır, Dilek Ülker; Akşit, Ercan; Çetin, Ece Ünal
    Objective: The levels of plasma preβ-HDL increase as the stages of chronic kidney disease (CKD) progress. Epicardial adipose tissue (EAT) increases the risk of cardiovascular incidents in patients with moderate to severe CKD. The aim of our study was to compare the levels of plasma preβ1-HDL with the EAT thickness on transthoracic echocardiography in patients with CKD (stage 3-5). Methods: Forty-four patients with CKD and 44 healthy volunteers (control group) were included in the study. Plasma preβ1-HDL was measured with ELISA (enzyme-linked immunosorbent assay) method in both groups. EAT thickness (both systole and diastole) was evaluated by the same cardiologist on the transthoracic echocardiographic method only in the patient group. P < .05 was accepted as statistically significant. Results: The mean plasma preβ1-HDL level was higher in the patient group compared to the control group but did not reach statistical significance. It was determined that the level of mean preβ1-HDL was increased in CKD patients as the stages progress but the result was not statistically significant. When the level of mean plasma preβ1-HDL and EAT thickness of CKD patients were compared, a statistically significant and negative correlation was determined (P = .013, r = −0.398; P = .006, r = −0.441, respectively, for systole and diastole). Conclusion: We determined a statistically significant and negative relationship between the levels of plasma preβ1-HDL and EAT thickness in CKD patients.
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    Contradictory Effect of Coronary Collateral Circulation on Regional Myocardial Perfusion That Assessed by Quantitative Myocardial Perfusion Scintigraphy
    (Elmer Press, 2021) Özdemir, Semra; Barutçu, Ahmet; Akşit, Ercan; Duygu, Ali; Koç Öztürk, Fulya
    Background: Previous studies showed conflicting results about the contribution of coronary collateral circulation (CCC) to myocardial perfusion and function. The aim of this study was to investigate these contradictory problems by gated myocardial perfusion scintigraphy (gated MPS) for the first time. Methods: The current cohort was retrospectively selected among patients who underwent gated MPS and coronary angiography within 2 months. Two different groups including 96 patients were assessed by gated MPS to detect the understanding of the miscellaneous effect of CCC on myocardial perfusion. Group 1 consisted of those who had collateral arteries that were not-well-developed (Rentrop grade 0 - 1) (n = 58), while group 2 consisted of those who had collateral arteries that were well-developed (Rentrop grade 2 - 3) (n = 38). Results: There was no statistically significant difference between groups 1 and 2 in terms of perfusion and functional parameters obtained from gated MPS. Furthermore, no statistically significant difference was found in the phase analysis parameters which is a novel technique to evaluate left ventricular synchronization. On the other hand the left ventricular mass index values were high and quite close to the statistically significant value (P = 0.059) in group 2. Conclusions: The current results that obtained by using the gated MPS technique for the first time in the evaluation of CCC showed that the well-developed collateral circulation has a positive effect on myocardial perfusion and function, but this effect was not statistically significant. Results need to be supported by large scale of patients' size.
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    Digoxin Intoxication
    (Çanakkale Onsekiz Mart Üniversitesi, 2022) Küçük, Uğur; Kırılmaz, Bahadır; Aşgün, H. Fatih; Akşit, Ercan
    Digoxin is a cardiac glycoside used in the treatment of heart failure and arrhythmia. It has a positive effect on ventricular contraction. However, it causes a decrease in heart rate due to its negative effect on the atrioventricular (AV) node. The narrow therapeutic range of blood digoxin levels cause some concerns about the drug. Our aim in this article is to summarize the effects of digoxin on the cardiovascular system and current approaches in case of possible side effects.
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    Evaluation of atherogenic index of plasma levels at hypertensive patients
    (2019) Yıldırım, Özge Turgay; Akşit, Ercan; Aydın, Fatih; Aydın, Ayşe Hüseyinoğlu
    Aim: Hypertension is a major risk factor for cardiovascular system. Recent studies showed that atherogenic index of plasma (AIP) has a strong association with cardiovascular morbidity, all-cause mortality, atherosclerosis and severity of coronary artery disease. It also has a relationship with endothelial damage in hypertensive patients. With this study we aim to investigate the association between AIP and hypertension. Methods: A total of 213 patients were enrolled for the study. Patients with previous hypertension, nephrotic syndrome, diabetes mellitus, hypotiroidism diagnosis, patients under statin treatment and patients under 18 years of age were excluded. Diagnosis of hypertension and blood pressure (BP) results were obtained with 24-hour ambulatory blood pressure monitoring (ABPM). AIP was defined as the logarithmic transformation of the triglyceride to high-density lipoprotein-cholesterol ratio. Results: Mean age of the population was 49.2 ± 14.6 years and 41.8% (n=89) was male. According to 24-hour ABPM results, AIP was positively correlated with day-time systolic blood pressure (SBP) (r=0.244, p<0.001), day-time diastolic blood pressure (DBP) (r=0.276, p<0.001), night-time SBP (r=0.259, p<0.001), night-time DBP (r=0.299, p<0.001), average SBP (r=0.213, p=0.002) and average DBP (r=0.296, p<0.001). AIP was also increased in hypertensive patients compared to normotensive subjects (p=0.001). Conclusion: Results of our study showed that AIP was positively correlated with blood pressure and statistically higher in patients with hypertension.
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    Evaluation of Diastolic Dysfunction in Rheumatoid Arthritis Patients
    (Rojan GÜMÜŞ, 2018) Yıldırım, Özge Turgay; Gönüllü, Emel; Aydın, Fatih; Akşit, Ercan; Aydın, Ayşe Hüseyinoğlu; Dağtekin, Evrin
    Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disorder which can also affect cardiovascular system. Cardiovascular system involvement can be seen in many forms such as pericarditis, myocarditis, coronary artery disease or heart failure. Diastolic dysfunction is especially important for preserved ejection fraction heart failure patients. With this study we aim to investigate echocardiographic diastolic dysfunction parameters in RA patients.77 RA patients and 76 control subjects without coronary artery disease, heart failure, valvular heart diseases were included for the study and echocardiography was performed. Interventricular septum (p=0.041), posterior wall diameter (p=0.008), left ventricular mass index (p=0.037) values were significantly higher and E wave (p=0.000), E/A (p=0.000), e’ (p=0.018) values were significantly lower in RA patients compared to control group. In conclusion echocardiographic diastolic dysfunction parameters were declined in RA patients.
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    Evaluation of knowledge and awareness levels of drugs used in smoking cessation treatment
    (Pamukkale University, 2022) Çam, Mustafa; Akşit, Ercan
    Purpose: Smoking is among the modifiable risk factors for cardiovascular diseases and stroke. In the followups after quitting this habit, it has been shown that there is a decrease in the mortality rate related to the cardiovascular system and an increase in the quality of life of the patients. In this study, it was aimed to investigate the awareness of the drugs used in smoking cessation on patients and healthy individuals. Materials and methods: Our study was planned as cross-sectional. Patients who applied with any complaints and 198 volunteers from healthcare professionals working in the hospital were included. With the questions in the questionnaire, it was aimed to learn the awareness levels about the drugs used in smoking cessation. Results: In our study, it was determined that women and other professionals did not have statistically significant information in the question in which the effects of these drugs on pulse and blood pressure levels were evaluated. The statement that individuals in other occupational groups did not know about the effect of bupropion treatment on this system was found to be statistically significantly higher (p<0.01). Conclusion: In our study, participants' awareness of smoking cessation treatments was found to be low. Knowing these treatments and being able to prescribe these drugs safely if their patients are stable will have a very important place in the fight against smoking. © 2022, Pamukkale University. All rights reserved.
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    Glu 298-Asp And T786-C Polymorphisms Of Endothelial Nitric Oxide Synthase Gene In Coronary Artery Disease Patients
    (2019) Kaçmaz, Yücel; Gürlertop, Hanefi Yekta; Yıldırım, Özge Turgay; Akşit, Ercan; Aydın, Abdurrahman Fatih
    Aim: We aimed to investigate the association of eNOS gene with Glu298-Asp andT-786C polymorphisms with Coronary artery disease (CAD) and to contribute to theelucidation of the genetic factors involved in the development of CAD.Patients and Methods: A total of 200 patients were evaluated. Severe CAD was defined as ? 50% stenosis in at least one of major coronary arteries and these patientswere taken into the CAD group (n=144). Patients without stenosis were included inthe control group (n=66).Results: After the evaluation of T-786C polymorphism, there was no significant difference between TT (p=0,660), TC (p=0,73) and CC (p=0,634) genotypes betweenCAD and control groups. There was no significant difference between the groups inboth dominant (p=0,439) and recessive (p=0,622) model comparisons. When Glu298-Asp polymorphism was examined, there was no statistically significantdifference between GG (p=0,836), GT (p=0,581) and TT (p=0,767) genotypes whenthe groups were compared according to genotype distributions. The groups werestatistically similar according to both dominant (p=0,697) and recessive (p=0,485)model com-parisons.Conclusion: There was no statistical correlation between T-786 C and Glu 298-Asppolymorphisms and CAD. Similar studies with larger study populations should beconducted to clarify the role of T-786 C and Glu 298-Asp polymorphisms.