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    Castleman Hastalığı; Boyun Kitlelerinin Nadir Nedeni
    (Bolu Abant İzzet Baysal Üniversitesi, 2020) Çağlar, Özge; Kılıç, Aytaç; Güçlü, Oğuz; Göret, Ceren Canbey; Dereköy, Fevzi Sefa
    Castleman hastalığı, lenfoproliferatif hastalıkların heterojen bir grubu olup tek bir hastalık olarak düşünülmemelidir. Bu hastalık çeşitli klinik şekillerde ortaya çıkmaktadır. Üç histolojik çesidi olan hastalığın etyopatogenezinde IL-6, HİV ve HHV- 8 yer almaktadır. Bu hastalığı anlamada önemli yollar kat etmiş ve tedavi tecrübelerimiz rituximab, tokilizumab ve siltuximab gibi ilaçlarla artmış olsa da, halen etyolojisi, prognozu ve tedavisi hakkında cevapsız sorular bulunmaktadır. Aşağıdaki olgumuzda, meduller tiroid kanser tanısı ile takipte olan hasta boyunda kitle nedeni ile tarafımıza başvurmuş, boyun diseksiyonu sonrası patoloji sonucu castleman hastalığı olarak rapor edilmiştir
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    Öğe
    CHRONOTYPE AND QUALITY OF LIFE IN PATIENTS WITH ALLERGIC RHINITIS
    (2021) Çağlar, Özge; Tas, Halil İbrahim; Oymak, Sibel
    Objective: The aim of this study is to investigate the coronotypes and quality of life of patients with allergic rhinitis.Material Method: Our patient group consisted of 100 patients and our control group consisted of 74 patients. The patients with allergicrhinitis and the control group were selected from patients who did not have any other psychiatric or comorbid diseases and did not use anymedication. First, patients with symptoms for at least 6 months were diagnosed with allergic rhinitis with appropriate examinations ,followed by morning-evening test (MEQ) and quality of life test (SF-36). Results were compared statistically.Results: The average age of our study group is 32.03 ± 8.31. There was no difference between the control group and the patient group interms of age, gender and socioeconomic status. The number of those who were close to the evening type and definitely close to the eveningtype was higher in the patient group and it was statistically significant. It was observed that the parameters showing the quality of life in theevening type patients were worse.Conclusion: This study shows that patients with allergic rhinitis tend to have the evening type. This also reduces the quality of life. Thisshows us that the sleep and psychological states of patients with allergic rhinitis are also affected by the disease and this should be taken intoconsideration.
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    Öğe
    Circulating cell free DNA and miRNA Amount in Congenital Hearing Loss
    (2018) Çağlar, Özge; Çayır, Akın; Cılgın, Begum; Dereköy, F. Sefa
    Objective: Our aim is to detect the amount of miRNA and free DNA in the peripheral blood of young people with congenital hearing loss and compare this with control group.Materials and Methods: In our study, 16 patients who have congenital hearing lossand go to the private school for deaf children and 16 healthy individuals were select-ed in the same age group. 5 cc blood was taken from peripheral vessels of each individual. We compared the circulating cell-free DNA and miRNA amount with the results of the control group.Results: The ccfDNA amount of the patients with hearing loss was lower than thecontrol group and It was statistically significant. On the contrary, we found the high-er amount of ccfmiRNA in plasma samples of the patients with hearing loss. The statistical analysis showed that ccfmiRNA amount in congenital loss is consistently sig-nificantly higher than the control group.Conclusion: The miRNA and freeDNA can be used early in the diagnosis of congenital hearing loss.
  • Küçük Resim
    Öğe
    Evaluation of DNA damages in congenital hearing loss patients
    (Elsevier B.V., 2021) Çağlar, Özge; Çobanoğlu, Hayal; Uslu, Atilla; Çayır, Akın
    In the current study, we aimed to compare the level of genetic damages measured as micronucleus (MN), nucleoplasmic bridge (NPB), and nuclear bud formation (NBUD) in congenital hearing loss patients (n = 17) and control group (n = 24). The cytokinesis-blocked micronucleus assay (CBMN) was applied to the blood samples to measure the frequency of the markers in both groups. The frequencies of MN of hearing loss patients were found to be consistently significantly higher than those obtained for the control group (p < 0.0001). Similarly, we found significantly higher frequency of NPB in patients was obtained for the patient group (p < 0.0001). Finally, the frequencies of NBUD in patients is significantly higher than the level measured in the control group (p < 0.0001). Furthermore, the age-adjusted MNL, BNMN, NPB, and NBUD frequencies in the patients were significantly higher than those obtained in the control group. We observed that the frequency of MN in patients was positively correlated with NBUD frequency which may indicate a common mechanism for these biomarkers in the patient group. We found, for the first time, that there were statistically significant higher levels of MN, NPB, and NBUD in sensorineural hearing loss patients. Since the markers we evaluated were linked with crucial diseases, our findings might suggest that sensorineural hearing loss patients are susceptible to several crucial diseases, especially cancer. Furthermore, the results demonstrated the significance of the MN, NPB, and NBUD level and thus provides a potential marker for the diagnosis of congenital hearing loss patients.