The preventive effect of dopamine infusion in rats with abdominal compartment syndrome

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dc.contributor.authorSaracoglu, Kemal Tolga
dc.contributor.authorSaracoglu, Ayten
dc.contributor.authorUmuroglu, Tumay
dc.contributor.authorUgurlu, Mustafa Umit
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorGogus, Fevzi Yilmaz
dc.date.accessioned2025-01-27T18:59:13Z
dc.date.available2025-01-27T18:59:13Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The most significant perfusion disorder of the intra-abdominal viscera occurs in the abdominal compartment syndrome (ACS). Free oxygen radicals diffuse into the body during the reperfusion phase of ACS. Our aim was to determine the effects of dopamine infusion (3 ?g/kg/min) on renal perfusion, cytokine levels, free oxygen radicals, and renal histopathological changes in the presence of ACS in a prospective randomized manner. Methods: Twenty-four male Sprague-Dawley rats were randomly divided into four groups (n = 6). Group 1 was used as control. In group 2, air was inflated until the intra-abdominal pressure (IAP) reached 20 mmHg. In group 3, dopamine was infused for 60 min meanwhile IAP was kept at 20 mmHg. In group 4, dopamine was infused for 60 min before IAP rise. After this phase, renal artery (RA) perfusion was measured continuously. Myeloperoxidase activity (MPO), glutathione (GSH), and lipid peroxidation (MDA) levels were measured in tissue samples and histopathological scoring was performed. Results: Dopamine treatment before and during ACS significantly decreased MPO and MDA levels and also increased renal blood flow and GSH levels. However, histopathological damage was improved simultaneously. Conclusion: Dopamine infusion before and during ACS, increases renal perfusion and decreases free oxygen radicals. According to our findings, dopamine infusion may be proposed for the treatment of ACS and perfusion disorders in critically ill patients. Copyright © 2013 Informa Healthcare USA, Inc.
dc.identifier.doi10.3109/08941939.2013.808289
dc.identifier.endpage339
dc.identifier.issn1521-0553
dc.identifier.issue6
dc.identifier.pmid23957751
dc.identifier.scopus2-s2.0-84888183494
dc.identifier.scopusqualityQ1
dc.identifier.startpage334
dc.identifier.urihttps://doi.org/10.3109/08941939.2013.808289
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13194
dc.identifier.volume26
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectAbdominal compartment syndrome; Dopamine; Injury; Intra-abdominal hypertension; Ischemia reperfusion; Renal artery
dc.titleThe preventive effect of dopamine infusion in rats with abdominal compartment syndrome
dc.typeArticle

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