Evaluation of the pathologic results of prostate biopsies in terms of age, Gleason score and PSA level: Our experience and review of the literature

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dc.authoridSarikaya, Selcuk/0000-0001-6426-1398
dc.contributor.authorSarikaya, Selcuk
dc.contributor.authorResorlu, Mustafa
dc.contributor.authorOguz, Ural
dc.contributor.authorYordam, Mustafa
dc.contributor.authorBozkurt, Omer Faruk
dc.contributor.authorUnsal, Ali
dc.date.accessioned2025-01-27T21:19:55Z
dc.date.available2025-01-27T21:19:55Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To evaluate the pathologic and clinic results of our large series of transrectal prostate biopsies in relation to Gleason score, age and PSA level. Materials and Methods: We reviewed the pathologic results of transrectal prostate biopsies performed because of high PSA levels and abnormal digital rectal examination findings between January 2008 and February 2012. Results: The pathologic result of 835 prostate biopsies was benign in 82.2% and malign in 17.8%. Furthermore in 3.7% high grade PIN (Prostatic Intraepitelial Neoplasia) or ASAP (Atypical Small Acinar Proliferation) was shown. In the interval of total PSA values between 4 and 10 ng/dl, that is thw so-called grey zone, cancer detection rate was 12.4%. There was a significant relationship between cancer detection and cancer stage at all high levels of PSA also in the grey zone. The most common Gleason score observed was 3 + 3 wirh a rate of 7.4% whereas the second most commonly observed scare was 3 + 4 with a rate of 2.5%. In the patients with abnormal digital rectal examination findings but normal PSA levels according to age the cancer detection rate was 8.7%, in patients with only high PSA levels the rate was 41.2% and in the patients with both high PSA levels and abnormal digital rectal examination findings. the rate was 49.3%. Conclusion: Our study underlines the relationship between age, PSA level and pathologic stage of prostate cancer and also the importance of digital rectal examination.
dc.identifier.doi10.4081/aiua.2014.4.288
dc.identifier.endpage290
dc.identifier.issn1124-3562
dc.identifier.issn2282-4197
dc.identifier.issue4
dc.identifier.pmid25641453
dc.identifier.startpage288
dc.identifier.urihttps://doi.org/10.4081/aiua.2014.4.288
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28773
dc.identifier.volume86
dc.identifier.wosWOS:000440281700012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPagepress Publ
dc.relation.ispartofArchivio Italiano Di Urologia E Andrologia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectProstate biopsy
dc.subjectGleason score
dc.subjectProstate specific antigen
dc.titleEvaluation of the pathologic results of prostate biopsies in terms of age, Gleason score and PSA level: Our experience and review of the literature
dc.typeReview Article

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