Effects of environmental noise exposure on DNA methylation in the brain and metabolic health

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dc.authoridBarrow, Timothy/0000-0003-4551-3857
dc.authoridGuo, Liqiong/0000-0003-4539-5029
dc.authoridguo, liqiong/0000-0002-1141-9646
dc.authoridColicino, Elena/0000-0002-1875-8448
dc.authoridByun, Hyang-Min/0000-0002-6278-3165
dc.contributor.authorGuo, Liqiong
dc.contributor.authorLi, Peng-hui
dc.contributor.authorLi, Hua
dc.contributor.authorColicino, Elena
dc.contributor.authorColicino, Silvia
dc.contributor.authorWen, Yi
dc.contributor.authorZhang, Ruiping
dc.date.accessioned2025-01-27T20:20:13Z
dc.date.available2025-01-27T20:20:13Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractEnvironmental noise exposure is associated with adverse effects on human health including hearing loss, heart disease, and changes in stress-related hormone levels. Alteration in DNA methylation in response to environmental exposures is a well-known phenomenon and it is implicated in many human diseases. Understanding how environmental noise exposures affect DNA methylation patterns may help to elucidate the link between noise and adverse effects on health. In this pilot study we examined the effects of environmental noise exposure on DNA methylation of genes related to brain function and investigated whether these changes are related with metabolic health. We exposed four groups of male Wistar rats to moderate intensity noise (70-75 dB with 20-4000 Hz) at night for three days as short-term exposure, and for three weeks as long-term exposure. Noise exposure was limited to 45 dB during the daytime. Control groups were exposed to only 45 dB, day and night. We measured DNA methylation in the Bdnf, Comt, Crhr1, Mc2r, and Snca genes in tissue from four brain regions of the rats (hippocampus, frontal lobe, medulla oblongata, and inferior colliculus). Further, we measured blood pressure and body weight after long-term noise exposure. We found that environmental noise exposure is associated with gene-specific DNA methylation changes in specific regions of the brain. Changes in DNA methylation are significantly associated with changes in body weight (between Bdnf DNA methylation and A body weight: r=0.59, p=0.018; and between LINE-1 ORF DNA methylation and A body weight: =-0.80, p=0.0004). We also observed that noise exposure decreased blood pressure (p=0.038 for SBP, p=0.017 for DBP and p 0.017 for MAP) and decreased body weight (beta=-26 g, p=0.008). In conclusion, environmental noise exposures can induce changes in DNA methylation in the brain, which may be associated with adverse effects upon metabolic health through modulation of response to stress-related hormones.
dc.description.sponsorshipScience Foundation of Tianjin Medical University [2GW033]; National Natural Science Foundation of China [81602827, 41601548]
dc.description.sponsorshipThis work was supported by the Science Foundation of Tianjin Medical University [grant number 2GW033] and the National Natural Science Foundation of China [grant number 81602827 and 41601548].
dc.identifier.doi10.1016/j.envres.2016.11.017
dc.identifier.endpage82
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.pmid27914298
dc.identifier.startpage73
dc.identifier.urihttps://doi.org/10.1016/j.envres.2016.11.017
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21622
dc.identifier.volume153
dc.identifier.wosWOS:000392366500010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEnvironmental Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectEnvironmental noise stress
dc.subjectBrain
dc.subjectDNA methylation
dc.subjectEpigenetics
dc.titleEffects of environmental noise exposure on DNA methylation in the brain and metabolic health
dc.typeArticle

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