The Importance of Serum Omentin-1 and Visfatin Levels in Determining Acute Pancreatitis Activation

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dc.contributor.authorTekin, Dilara
dc.contributor.authorKurtkulağı, Özge
dc.contributor.authorDaş, Murat
dc.contributor.authorÇinpolat, Havva Yasemin
dc.contributor.authorBeyazıt, Yavuz
dc.date.accessioned2025-05-29T05:36:37Z
dc.date.available2025-05-29T05:36:37Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground Acute pancreatitis is a disease that can lead to serious mortality and morbidity. Therefore, the use of inflammatory markers is of great importance in determining the prognosis of the disease. Omentin-1 and visfatin are newly discovered adipokines associated with inflammation. In this study, we aimed to demonstrate the importance of omentin-1 and visfatin in diagnosing and activating acute pancreatitis. Methods Serum samples from 52 patients diagnosed with acute pancreatitis who presented to the Emergency Department of Çanakkale Onsekiz Mart University Health Practice and Research Hospital between July 2022 and May 2023 were analyzed for serum omentin-1 and visfatin levels, along with routine laboratory tests, during both the initial and remission periods. Disease severity was calculated using the Modified Glasgow Prognostic Score. Correlation analysis was conducted among study variables. Results The marker with the highest sensitivity and specificity in predicting active disease was found to be C-reactive protein (CRP). The sensitivity of serum omentin-1 levels in determining active disease was 84.62%, with a specificity of 73.17%. Serum visfatin levels had a sensitivity of 76.92% and a specificity of 78.05% in determining active disease. According to the Modified Glasgow Prognostic Scoring System, omentin showed the highest sensitivity (82.61%) in distinguishing mild-moderate cases from severe cases, while visfatin had the highest specificity (86.21%). Conclusion In our study, serum levels of omentin-1 and visfatin negatively correlated with disease diagnosis and severity.
dc.identifier.doi10.46310/tjim.1544674
dc.identifier.endpage80
dc.identifier.issn2687-4245
dc.identifier.issue2
dc.identifier.startpage71
dc.identifier.urihttps://doi.org/10.46310/tjim.1544674
dc.identifier.urihttps://hdl.handle.net/20.500.12428/31390
dc.identifier.volume7
dc.language.isoen
dc.publisherNizameddin KOCA
dc.relation.ispartofTurkish Journal of Internal Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250529
dc.subjectAcute Pancreatitis
dc.subjectOmentin-1
dc.subjectVisfatin
dc.subjectCRP
dc.titleThe Importance of Serum Omentin-1 and Visfatin Levels in Determining Acute Pancreatitis Activation
dc.typeResearch Article

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