Assessment of the Cytotoxicity of Melia azedarach L. Extracts on Human Adipose-derived Mesenchymal Stem Cells

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dc.contributor.authorEfe, Burcu
dc.contributor.authorGalata, Yusuf Furkan
dc.contributor.authorArslan, Yavuz Emre
dc.date.accessioned2025-01-27T19:15:22Z
dc.date.available2025-01-27T19:15:22Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, aqueous extracts of Melia azedarach L. green fruit and leaves were obtained using two different extraction methods. The extraction yields of the green fruit and leaves were found as 24.11% and 37.98% for the infusion method; 17.76% and 27.00% for the rotating method, respectively. The total phenolic content, related to the infusion method, was ascertained for green fruit extract 173.67±10.84 mg Gallic Acid Equivalent (GAE)/g dry weight and leaf extract 312.33±9.81 mg GAE/g dry weight. In other respects, antioxidant activity related to the infusion method was determined for green fruit extract 172.51±13.23 mg Trolox/L and leaf extract 569.16±10.41 mg Trolox/L. Gas chromatography-mass spectrometry (GC-MS) analysis was performed to identify the chemical composition of the extracts. The cytotoxicity levels of the extracts were assessed on human adipose-derived mesenchymal stem cells (hAMSCs) using commercially available XTT assay. Consequently, it has been found that the green fruit extract has more cytotoxic activity than the leaf extract on hAMSCs.
dc.identifier.doi10.15671/HJBC.2018.220
dc.identifier.endpage128
dc.identifier.issn1303-5002
dc.identifier.issn2687-475X
dc.identifier.issue1
dc.identifier.startpage121
dc.identifier.trdizinid286787
dc.identifier.urihttps://doi.org/10.15671/HJBC.2018.220
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/286787
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14806
dc.identifier.volume46
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofHacettepe Journal of Biology and Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectHücre ve Doku Mühendisliği
dc.subjectKimya
dc.subjectTıbbi
dc.subjectHücre Biyolojisi
dc.subjectFarmakoloji ve Eczacılık
dc.titleAssessment of the Cytotoxicity of Melia azedarach L. Extracts on Human Adipose-derived Mesenchymal Stem Cells
dc.typeArticle

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