EFFECTS OF CORTICOSTEROID AND ANTIHISTAMINIC INJECTIONS ON COLD-INDUCED STRESS ON RAT BLADDER TISSUE: AN EXPERIMENTAL STUDY

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dc.contributor.authorEroğlu, Hüseyin Avni
dc.contributor.authorBüyük, Başak
dc.contributor.authorAdalı, Yasemen
dc.contributor.authorDemir, Aslan
dc.date.accessioned2025-01-27T19:26:44Z
dc.date.available2025-01-27T19:26:44Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Cold is a stress-inducing factor that can cause changes in bladder function in various ways. The present study is intended to investigate the effects of corticosteroid and antihistaminic treatment on acutely and chronically induced cold stress. Material and Methods: Forty-two female rats were randomly divided into seven groups as follows: Control group; Acute cold-stress (ACS) group; ACS+ corticosteroid (CORT) group; ACS+CORT + Antihistaminic group; Cronic cold-stres (CCS) group; CSS+CORT group; CSS+CORT+Antihistaminic group. On the 15th day after these treatments, bladders of the rats were harvested for histopathological examinations under general anesthesia and fixed with 10% neutral buffered formaline. Hematoxylin and eosin and toluidine blue stainings were performed. Results: The comparison based on mast cell count yielded the highest value in the CCS group in comparison to the control group. The lowest value was harvested in the CCS + CORT group. The comparison between the CCS groups revealed the highest polymorphonuclear leucocyte (PNL) values in the lamina propria in the CCS group, whereas the CORT and CORT + Antihistaminic treatments were found to have significantly decreased the PNL values in the lamina propria. While the PNL counts in the epithelium were high in the ACS and CCS groups, the results in the ACS and CCS groups that were treated with CORT and/or antihistaminic were revealed to be similar with those in the control group. It was discovered that antihistaminic injection in addition to CORT decreased the lymphocyte counts in epithelium in CCS more efficiently than CORT alone did. Conclusion: The present research revealed that corticosteroid treatment reduced inflammatory cell infiltration and decreased mast cell count. A more evident amelioration was observed particularly in chronic cold stress.
dc.identifier.doi10.24938/kutfd.621514
dc.identifier.endpage19
dc.identifier.issn2148-9645
dc.identifier.issue1
dc.identifier.startpage11
dc.identifier.trdizinid377777
dc.identifier.urihttps://doi.org/10.24938/kutfd.621514
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/377777
dc.identifier.urihttps://hdl.handle.net/20.500.12428/15610
dc.identifier.volume22
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKırıkkale Üniversitesi Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectFizyoloji
dc.titleEFFECTS OF CORTICOSTEROID AND ANTIHISTAMINIC INJECTIONS ON COLD-INDUCED STRESS ON RAT BLADDER TISSUE: AN EXPERIMENTAL STUDY
dc.typeArticle

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