Glu 298-Asp And T786-C Polymorphisms Of Endothelial Nitric Oxide Synthase Gene In Coronary Artery Disease Patients

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dc.contributor.authorKaçmaz, Yücel
dc.contributor.authorGürlertop, Hanefi Yekta
dc.contributor.authorYıldırım, Özge Turgay
dc.contributor.authorAkşit, Ercan
dc.contributor.authorAydın, Abdurrahman Fatih
dc.date.accessioned2025-01-27T19:30:22Z
dc.date.available2025-01-27T19:30:22Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: We aimed to investigate the association of eNOS gene with Glu298-Asp andT-786C polymorphisms with Coronary artery disease (CAD) and to contribute to theelucidation of the genetic factors involved in the development of CAD.Patients and Methods: A total of 200 patients were evaluated. Severe CAD was defined as ? 50% stenosis in at least one of major coronary arteries and these patientswere taken into the CAD group (n=144). Patients without stenosis were included inthe control group (n=66).Results: After the evaluation of T-786C polymorphism, there was no significant difference between TT (p=0,660), TC (p=0,73) and CC (p=0,634) genotypes betweenCAD and control groups. There was no significant difference between the groups inboth dominant (p=0,439) and recessive (p=0,622) model comparisons. When Glu298-Asp polymorphism was examined, there was no statistically significantdifference between GG (p=0,836), GT (p=0,581) and TT (p=0,767) genotypes whenthe groups were compared according to genotype distributions. The groups werestatistically similar according to both dominant (p=0,697) and recessive (p=0,485)model com-parisons.Conclusion: There was no statistical correlation between T-786 C and Glu 298-Asppolymorphisms and CAD. Similar studies with larger study populations should beconducted to clarify the role of T-786 C and Glu 298-Asp polymorphisms.
dc.identifier.doi10.30565/medalanya.469411
dc.identifier.endpage48
dc.identifier.issn2587-0319
dc.identifier.issue1
dc.identifier.startpage40
dc.identifier.trdizinid371752
dc.identifier.urihttps://doi.org/10.30565/medalanya.469411
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/371752
dc.identifier.urihttps://hdl.handle.net/20.500.12428/16086
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofActa Medica Alanya
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectGenetik ve Kalıtım
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleGlu 298-Asp And T786-C Polymorphisms Of Endothelial Nitric Oxide Synthase Gene In Coronary Artery Disease Patients
dc.typeArticle

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