The effects of ozone therapy on extremity ischemiareperfusion injury in a rabbit model

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dc.contributor.authorKaymaz, Burak
dc.contributor.authorÇoban, Ganime
dc.contributor.authorGöksel, Ferdi
dc.contributor.authorToman, Hüseyin
dc.contributor.authorGölge, Umut Hatay
dc.contributor.authorKömürcü, Erkam
dc.date.accessioned2025-01-27T20:01:34Z
dc.date.available2025-01-27T20:01:34Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Ischemia is reversible or irreversible cell/tissue damage that is secondary to insufficient blood flow to tissues or organs. Ischemia causesmany metabolic and structural changes at the cellular level. Ozone therapy is often used as an antioxidant remedy. This study aimed to investigate theeffects of ozone therapy on extremity ischemia-reperfusion (IR) injury.Methods: Twenty-four New Zealand White (NZW) rabbits were randomly allocated into three groups. Each group consisted of eight rabbits. Group Iwas the control group, Group II was the ischemia group, and Group III, the ozone group. Femoral arteries of the right legs were dissected, and femoralarterial occlusion was performed in Group II and III. Hematological and histopathological evaluation was performed in all groups.Results: The levels of total antioxidant status (TAS) after the surgical procedure was higher in the ozone group compared to the ischemia group(p=0.036). In addition, the levels of malondialdehyde (MDA) after the surgical procedure were lower in the ozone group compared to the ischemiagroup but not statistically significant (p=0.093). The control and ozone groups were histopathologically similar.Conclusions: Ozone therapy may be used as an alternative treatment modality with its anti-inflammatory and antioxidant effects for the treatment ofextremity IR injury
dc.identifier.endpage84
dc.identifier.issn2458-8865
dc.identifier.issn2459-1505
dc.identifier.issue3
dc.identifier.startpage79
dc.identifier.trdizinid372046
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/372046
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20138
dc.identifier.volume4
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAile Hekimliği ve Palyatif Bakım
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.titleThe effects of ozone therapy on extremity ischemiareperfusion injury in a rabbit model
dc.typeArticle

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